Literature DB >> 4018894

Synthesis and some characteristics of no-carrier added [18F]fluorotrimethylsilane.

M S Rosenthal, A L Bosch, R J Nickles, S J Gatley.   

Abstract

[18F]Fluorotrimethylsilane was prepared in 80% decay corrected yield by reaction of no-carrier added tetramethyl-ammonium fluoride (hydroxide as bulk anion) with chlorotrimethylsilane in 65% aqueous acetonitrile. The 18F gas was collected in a cold-trap at -130 degrees C and found to have an Ostwald solubility coefficient of 11.5 in paraffin oil. Accurate measurement of its aqueous solubility was precluded by hydrolysis. When rats were allowed to inhale [18F]fluorotrimethylsilane extensive uptake of 18F occurred in bone, demonstrating ready release of fluoride in vivo.

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Year:  1985        PMID： 4018894     DOI： 10.1016/0020-708x(85)90094-8

Source DB:  PubMed          Journal:  Int J Appl Radiat Isot        ISSN： 0020-708X


  8 in total

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4.  SNAr Radiofluorination with In Situ Generated [18F]Tetramethylammonium Fluoride.

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7.  Automated synthesis of [18F]Ga-rhPSMA-7/ -7.3: results, quality control and experience from more than 200 routine productions.

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Review 8.  Reaction of [18F]Fluoride at Heteroatoms and Metals for Imaging of Peptides and Proteins by Positron Emission Tomography.

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  8 in total

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