Literature DB >> 4018545

Influence of antioxidants and radical scavengers on ethanol-induced gastric ulcers in the rat.

S Evangelista, A Meli.   

Abstract

Sodium benzoate in doses which do not possess antisecretory properties, produced a dose-dependent reduction of ethanol-induced gastric lesions in the rat. Indomethacin pretreatment antagonized sodium benzoate-ulcer reducing properties indicating that this latter acts, at least in part, through stimulation of prostaglandins synthesis. Propyl gallate reduced ethanol-induced gastric lesions in doses which exert antisecretory properties.

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Year:  1985        PMID： 4018545     DOI： 10.1016/0306-3623(85)90085-0

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  6 in total

1.  Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro.

Authors:  L A Reinke; E K Lai; C M DuBose; P B McCay
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

2.  Sulfhydryls and gastric mucosa protection.

Authors:  S Evangelista; A Meli
Journal:  Dig Dis Sci       Date:  1988-10       Impact factor: 3.199

3.  Caffeic acid inhibits the formation of 1-hydroxyethyl radical in the reaction mixture of rat liver microsomes with ethanol partly through its metal chelating activity.

Authors:  Hideyuki Ikeda; Yuka Kimura; Miho Masaki; Hideo Iwahashi
Journal:  J Clin Biochem Nutr       Date:  2011-01-07       Impact factor: 3.114

4.  Gastric mucosal injury and associated changes in mucosal blood flow and gastric fluid secretion caused by dimethyl sulfoxide (DMSO) in rats.

Authors:  H Sørbye; K Guttu; H Gislason; K Grong; K Svanes
Journal:  Dig Dis Sci       Date:  1993-07       Impact factor: 3.199

5.  Protective effect of dimethylthiourea against mucosal injury in rat stomach. Implications for hydroxyl radical mechanism.

Authors:  G S Smith; J C Barreto; K L Schmidt; M S Tornwall; T A Miller
Journal:  Dig Dis Sci       Date:  1992-09       Impact factor: 3.199

6.  Nitric oxide as a mediator of gastrointestinal mucosal injury?-Say it ain't so.

Authors:  P Kubes; J L Wallace
Journal:  Mediators Inflamm       Date:  1995       Impact factor: 4.711
  6 in total

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