Literature DB >> 4018269

Thioridazine: a selective inhibitor of peroxisomal beta-oxidation in vivo.

C Van den Branden, F Roels.   

Abstract

In vivo administration of the phenothiazine drug, thioridazine, inhibits hepatic peroxisomal beta-oxidation in mice. In starving animals, 3-hydroxybutyrate concentration is not decreased by thioridazine treatment. These results provide the first demonstration of thioridazine as a selective inhibitor of peroxisomal beta-oxidation in intact animals. Thioridazine might supply a tool for simulation of pathological conditions in which peroxisomal beta-oxidation is impaired.

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Year:  1985        PMID： 4018269     DOI： 10.1016/0014-5793(85)81270-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Docosahexaenoic acid is both a product of and a precursor to tetracosahexaenoic acid in the rat.

Authors:  Adam H Metherel; R J Scott Lacombe; Raphaël Chouinard-Watkins; Richard P Bazinet
Journal:  J Lipid Res       Date:  2018-12-20       Impact factor: 5.922

Review 2.  On the molecular etiology of decreased arachidonic (20:4n-6), docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids in Zellweger syndrome and other peroxisomal disorders.

Authors:  J P Infante; V A Huszagh
Journal:  Mol Cell Biochem       Date:  1997-03       Impact factor: 3.396

3.  Different types of peroxisomes in human duodenal epithelium.

Authors:  F Roels; M Espeel; M Pauwels; D De Craemer; H J Egberts; P van der Spek
Journal:  Gut       Date:  1991-08       Impact factor: 23.059

4.  Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages.

Authors:  Tamas Kriska; Michael J Thomas; John R Falck; William B Campbell
Journal:  J Lipid Res       Date:  2018-02-22       Impact factor: 5.922

5.  Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis.

Authors:  Francesca Pala; Daniela Di Girolamo; Sébastien Mella; Siham Yennek; Laurent Chatre; Miria Ricchetti; Shahragim Tajbakhsh
Journal:  J Cell Sci       Date:  2018-07-27       Impact factor: 5.285

6.  Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration.

Authors:  Maria Tsachaki; Pirmin Strauss; Anja Dunkel; Hana Navrátilová; Natasa Mladenovic; Alex Odermatt
Journal:  Cell Mol Life Sci       Date:  2019-07-13       Impact factor: 9.261

7.  Fatty Acid and Carnitine Metabolism Are Dysregulated in Systemic Sclerosis Patients.

Authors:  A Ottria; A T Hoekstra; M Zimmermann; M van der Kroef; N Vazirpanah; M Cossu; E Chouri; M Rossato; L Beretta; R G Tieland; C G K Wichers; E Stigter; C Gulersonmez; F Bonte-Mineur; C R Berkers; T R D J Radstake; W Marut
Journal:  Front Immunol       Date:  2020-05-22       Impact factor: 7.561

8.  Peroxisomes Regulate Cellular Free Fatty Acids to Modulate Mast Cell TLR2, TLR4, and IgE-Mediated Activation.

Authors:  Dihia Meghnem; Edwin Leong; Marinella Pinelli; Jean S Marshall; Francesca Di Cara
Journal:  Front Cell Dev Biol       Date:  2022-05-13

9.  Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis.

Authors:  Florian J Weisel; Mark J Shlomchik; Steven J Mullett; Rebecca A Elsner; Ashley V Menk; Nikita Trivedi; Wei Luo; Daniel Wikenheiser; William F Hawse; Maria Chikina; Shuchi Smita; Laura J Conter; Stephen M Joachim; Stacy G Wendell; Michael J Jurczak; Thomas H Winkler; Greg M Delgoffe
Journal:  Nat Immunol       Date:  2020-02-17       Impact factor: 25.606

10.  Inhibition of Fatty Acid Oxidation as a New Target To Treat Primary Amoebic Meningoencephalitis.

Authors:  Maarten J Sarink; Aloysius G M Tielens; Annelies Verbon; Robert Sutak; Jaap J van Hellemond
Journal:  Antimicrob Agents Chemother       Date:  2020-07-22       Impact factor: 5.191
  10 in total

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