Literature DB >> 4018254

1H NMR detection of cerebral myo-inositol.

S Cerdàn, R Parrilla, J Santoro, M Rico.   

Abstract

A previously unassigned group of prominent multiplets of the 360 MHz 1H NMR spectrum of acid stable metabolite extracts from rat brain is shown to arise from free myo-inositol. This conclusion is derived from a systematic analysis of the high-resolution 1H NMR spectra of brain acid extracts, in which appropriate conditions and optimal proton signals have been selected for the quantitative analysis of up to 15 metabolites. Developmental variations in the cerebral content of myo-inositol could be readily detected using this approach, which provides a novel alternative to study myo-inositol metabolism under physiological or pathological conditions.

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Year:  1985        PMID： 4018254     DOI： 10.1016/0014-5793(85)81235-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

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7.  Correlation of myo-inositol levels and grading of cerebral astrocytomas.

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9.  Metabolic studies of human primitive neuroectodermal tumour cells by proton nuclear magnetic resonance spectroscopy.

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10.  The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism.

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Journal:  Nat Commun       Date:  2014-04-29       Impact factor: 14.919
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