Literature DB >> 401777

Pathogenesis of corneal damage from pseudomonas exotoxin A.

B H Iglewski, R P Burns, I K Gipson.   

Abstract

Pseudomonas aeruginosa exotoxin A was injected into rabbit corneas. Death of epithelial, endothelial, and stromal cells resulted, and necrosis of the cornea followed. Control eyes with exotoxin neutralized by specific antitoxin showed minimal damage. A dose-response pattern was evident. Antitoxin neutralization of pseudomonas exotoxin A in corneal ulcers may have possible therapeutic implications.

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Year:  1977        PMID： 401777

Source DB:  PubMed          Journal:  Invest Ophthalmol Vis Sci        ISSN： 0146-0404            Impact factor:   4.799


  20 in total

1.  Effect of iron on yields of exotoxin A in cultures of Pseudomonas aeruginosa PA-103.

Authors:  M J Bjorn; B H Iglewski; S K Ives; J C Sadoff; M L Vasil
Journal:  Infect Immun       Date:  1978-03       Impact factor: 3.441

2.  VIP and growth factors in the infected cornea.

Authors:  Xiaoyu Jiang; Sharon A McClellan; Ronald P Barrett; Elizabeth A Berger; Yunfan Zhang; Linda D Hazlett
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-08-03       Impact factor: 4.799

Review 3.  Experimental Pseudomonas keratitis.

Authors:  R A Hyndiuk
Journal:  Trans Am Ophthalmol Soc       Date:  1981

4.  Microscopic characterization of ocular damage produced by Pseudomonas aeruginosa toxin A.

Authors:  L D Hazlett; R S Berk; B H Iglewski
Journal:  Infect Immun       Date:  1981-12       Impact factor: 3.441

5.  Norfloxacin and silver norfloxacin in the treatment of Pseudomonas corneal ulcer in the rabbit.

Authors:  R W Darrell; S M Modak; C L Fox
Journal:  Trans Am Ophthalmol Soc       Date:  1984

6.  Inhibition of Pseudomonas aeruginosa elastase and Pseudomonas keratitis using a thiol-based peptide.

Authors:  F R Burns; C A Paterson; R D Gray; J T Wells
Journal:  Antimicrob Agents Chemother       Date:  1990-11       Impact factor: 5.191

7.  Modulatory effect of iron on the pathogenesis of Pseudomonas aeruginosa mouse corneal infections.

Authors:  D E Woods; P A Sokol; B H Iglewski
Journal:  Infect Immun       Date:  1982-02       Impact factor: 3.441

8.  Therapeutic intervention with chicken egg white ovomacroglobulin and a new quinolone on experimental Pseudomonas keratitis.

Authors:  S Miyagawa; R Kamata; K Matsumoto; R Okamura; H Maeda
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1994-08       Impact factor: 3.117

9.  Inhibitory effects of ovomacroglobulin on bacterial keratitis in rabbits.

Authors:  S Miyagawa; R Kamata; K Matsumoto; R Okamura; H Maeda
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1991       Impact factor: 3.117

10.  Purification of Pseudomonas aeruginosa proteases and microscopic characterization of pseudomonal protease-induced rabbit corneal damage.

Authors:  A S Kreger; L D Gray
Journal:  Infect Immun       Date:  1978-02       Impact factor: 3.441
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