Literature DB >> 4017289

Anti-acetylcholine receptor idiotypes in myasthenia gravis analysed by rabbit anti-sera.

B Lang, A J Roberts, A Vincent, J Newsom-Davis.   

Abstract

Anti-idiotype sera, raised in rabbits against anti-acetylcholine receptor (AChR) (idiotype) purified from the serum of three myasthenia gravis patients, inhibited binding of homologous idiotype to the AChR by up to 80%. The expression of idiotype in the three individuals changed very little over a period of several years, during which they showed a declining trend in overall anti-AChR antibody. Only one of the four anti-idiotype sera inhibited the binding of anti-AChR from a number of other patients. Our results indicate a consistency of idiotype expression within an individual, and fail to show substantial idiotype sharing between individuals.

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Year:  1985        PMID： 4017289      PMCID： PMC1577199     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  14 in total

Review 1.  Immunology of acetylcholine receptors in relation to myasthenia gravis.

Authors:  A Vincent
Journal:  Physiol Rev       Date:  1980-07       Impact factor: 37.312

2.  Induction of anti-idiotypic antibodies by immunisation with syngeneic spleen cells educated with acetylcholine receptor.

Authors:  M Schwartz; D Novick; D Givol; S Fuchs
Journal:  Nature       Date:  1978-06-15       Impact factor: 49.962

3.  Lack of inter-animal cross-reaction of anti-acetylcholine receptor antibodies at the receptor-binding site as demonstrated by heterologous anti-idiotype antisera: implications for immunotherapy of myasthenia gravis.

Authors:  T Barkas; J A Simpson
Journal:  Clin Exp Immunol       Date:  1982-01       Impact factor: 4.330

4.  Monoclonal autoantibodies to acetylcholine receptors: evidence for a dominant idiotype and requirement of complement for pathogenicity.

Authors:  V A Lennon; E H Lambert
Journal:  Ann N Y Acad Sci       Date:  1981       Impact factor: 5.691

5.  Acetylcholine receptor antibody characteristics in myasthenia gravis. I. Patients with generalized myasthenia or disease restricted to ocular muscles.

Authors:  A Vincent; J Newsom-Davis
Journal:  Clin Exp Immunol       Date:  1982-08       Impact factor: 4.330

6.  Purification of anti-acetylcholine receptor antibody from patients with myasthenia gravis.

Authors:  B Lang; A Vincent; J Newsom-Davis
Journal:  J Immunol Methods       Date:  1982       Impact factor: 2.303

7.  Specificities of antibodies to acetylcholine receptors.

Authors:  J Lindstrom; M Campbell; B Nave
Journal:  Muscle Nerve       Date:  1978 Mar-Apr       Impact factor: 3.217

8.  Anti-idiotypic antibodies against the receptor antibodies in myasthenia gravis.

Authors:  A K Lefvert
Journal:  Scand J Immunol       Date:  1981       Impact factor: 3.487

9.  Function of circulating antibody to acetylcholine receptor in myasthenia gravis: investigation by plasma exchange.

Authors:  J Newsom-Davis; A J Pinching; A Vincent; S G Wilson
Journal:  Neurology       Date:  1978-03       Impact factor: 9.910

10.  Anti-idiotypic antisera in man. I. Production and immunochemical characterization of anti-idiotypic antisera to human antitetanus antibodies.

Authors:  R S Geha; R P Weinberg
Journal:  J Immunol       Date:  1978-10       Impact factor: 5.422
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  2 in total

Review 1.  The idiotype-antiidiotype network in human autoimmunity.

Authors:  N I Abdou
Journal:  J Clin Immunol       Date:  1985-11       Impact factor: 8.317

2.  Treatment of experimental myasthenia with autologous idiotypes linked to muramyl dipeptide.

Authors:  R Valderrama; A E Eggers; M Moomjy; P N Kao; J Michl
Journal:  Clin Exp Immunol       Date:  1988-07       Impact factor: 4.330
  2 in total

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