| Literature DB >> 4016761 |
H I Robins, W H Dennis, A J Neville, L M Shecterle, P A Martin, J Grossman, T E Davis, S R Neville, W K Gillis, B F Rusy.
Abstract
A Phase I study of whole-body hyperthermia (WBH) (52 treatments/12 patients) was completed with no significant clinical toxicity. The study incorporated a thermal dose escalation scheme from 39.5 degrees-41.8 degrees C for up to 151 min. A radiant-heat device was utilized for producing WBH. During WBH, patients were sedated; endotracheal intubation was not required. No changes in cardiovascular, respiratory, hematological, or biochemical indices requiring clinical intervention occurred during the study. We conclude the radiant-heat device coupled with a defined pharmacological approach to WBH with appropriate patient screening yields a system for 41.8 degrees C WBH which is safe and efficient, is not labor intensive, and does not require general anesthesia and endotracheal intubation. This system is appropriate for a multimodality approach to various systemic cancers.Entities:
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Year: 1985 PMID： 4016761
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701