An electrochemical approach to sleep metabolism: a pO2 paradoxical sleep system.

Oxygen cathodes chronically implanted in the cat brain recorded changes of local oxygen concentration during paradoxical sleep. Phasic high amplitude pO2 changes were consistently observed in some regions and were characterized by a dramatic increase in the amplitude of the oscillations. The regions displaying these responses included part of the reticular formation, hypothalamus, amygdala and cerebellum which we refer to as the "pO2 paradoxical sleep system." This pO2 pattern was not observed in white matter, in the neocortex or in specific thalamic nuclei. It is postulated that the phasic response is due to a local increase of neuronal activity requiring increased oxygen availability and augmented protein synthesis during paradoxical sleep and may form part of a system related to "plastic" phenomena.