Stimulation of phospholipid turnover by angiotensin II and phenylephrine in proximal convoluted tubules microdissected from mouse nephron.

Angiotensin II and phenylephrine significantly increased phospholipid turnover in cortical tubule suspensions. To further localize this effect we studied the 32P incorporation into phosphatidylcholine (PC) and phosphatidylinositol (PI) in single dissected proximal convoluted tubules of mouse nephron. Both hormones significantly stimulated 32P labeling of PC and PI indicating that the proximal tubule is a target site of angiotensin II and phenylephrine action.