Literature DB >> 4011131

Lactate transport through the blood-retinal and the blood-brain barrier in rats.

A Alm, P Törnquist.   

Abstract

The retinal and brain uptake index method was utilized in a study on rats to evaluate the existence of transport systems for lactate in the blood-retinal and the blood-brain barrier, respectively. For both retina and brain a saturable, pH-dependent uptake of L-lactate was observed. The uptake could also be inhibited by pyruvate and 3-hydroxybutyrate. It is concluded that lactate is transported through the blood-retinal and the blood-brain barriers by similar carrier-mediated transport systems with affinity also to other monocarboxylic acids, such as pyruvate, and to the ketone body 3-hydroxybutyrate. The pH-dependence of the lactate transport suggests that co-transport of H+ ions or counter-transport of OH- ions takes place.

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Year:  1985        PMID： 4011131     DOI： 10.1159/000265371

Source DB:  PubMed          Journal:  Ophthalmic Res        ISSN： 0030-3747            Impact factor:   2.892


  8 in total

Review 1.  Inner blood-retinal barrier transporters: role of retinal drug delivery.

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Journal:  Pharm Res       Date:  2009-07-01       Impact factor: 4.200

2.  Retinal transfer of nicotinate by H+ -monocarboxylate transporter at the inner blood-retinal barrier.

Authors:  Masanori Tachikawa; Koji Murakami; Pamela M Martin; Ken-ichi Hosoya; Vadivel Ganapathy
Journal:  Microvasc Res       Date:  2011-06-29       Impact factor: 3.514

3.  MCT1-mediated transport of L-lactic acid at the inner blood-retinal barrier: a possible route for delivery of monocarboxylic acid drugs to the retina.

Authors:  K Hosoya; T Kondo; M Tomi; H Takanaga; S Ohtsuki; T Terasaki
Journal:  Pharm Res       Date:  2001-12       Impact factor: 4.200

4.  Altered visual function in monocarboxylate transporter 3 (Slc16a8) knockout mice.

Authors:  Lauren L Daniele; Brian Sauer; Shannon M Gallagher; Edward N Pugh; Nancy J Philp
Journal:  Am J Physiol Cell Physiol       Date:  2008-06-04       Impact factor: 4.249

Review 5.  Role of monosaccharide transport proteins in carbohydrate assimilation, distribution, metabolism, and homeostasis.

Authors:  Anthony J Cura; Anthony Carruthers
Journal:  Compr Physiol       Date:  2012-04       Impact factor: 9.090

6.  Monitoring the modifications of the vitreous humor metabolite profile after death: an animal model.

Authors:  Maria Francesca Rosa; Paola Scano; Antonio Noto; Matteo Nioi; Roberta Sanna; Francesco Paribello; Fabio De-Giorgio; Emanuela Locci; Ernesto d'Aloja
Journal:  Biomed Res Int       Date:  2015-01-22       Impact factor: 3.411

7.  Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System.

Authors:  Jason Charng; Zheng He; Algis J Vingrys; Rebecca L Fish; Rachel Gurrell; Bang V Bui; Christine T Nguyen
Journal:  J Ophthalmol       Date:  2016-04-27       Impact factor: 1.909

8.  The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.

Authors:  Maria Consiglia Trotta; Rosa Maisto; Francesca Guida; Serena Boccella; Livio Luongo; Cornel Balta; Giovanbattista D'Amico; Hildegard Herman; Anca Hermenean; Claudio Bucolo; Michele D'Amico
Journal:  PLoS One       Date:  2019-01-18       Impact factor: 3.240
  8 in total

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