| Literature DB >> 4010698 |
J Meyne, D C Allison, K Bose, S W Jordan, P F Ridolpho, J Smith.
Abstract
We report on a study of the cytogenetic and hepatotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mice of the C57B1/6J (with high-affinity TCDD receptor) or DBA/2J (with low-affinity TCDD receptor) strains were given single intraperitoneal injections of 50, 100 or 150 micrograms of TCDD/kg body weight. At various times (8-48 h) after injection, we examined bone marrow cells for cytogenetic effects by performing structural aberration, sister-chromatid exchange, and micronucleus tests. 1 month after exposure, liver sections were studied for hepatotoxic effects. We found no evidence of chromosome damage by TCDD given in doses that cause liver damage in both strains of mice.Entities:
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Year: 1985 PMID： 4010698 DOI： 10.1016/0165-1218(85)90050-3
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433