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Literature DB >> 4010488

Increased arachidonate incorporation in perfused heart phospholipids from vitamin E-deficient rats.

A C Chan, B Fragiskos, C E Douglas, P C Choy.

Abstract

When perfused with exogenous arachidonic acid (AA), the rat heart incorporates this eicosanoid precursor into the phospholipids. The incorporation of AA into phosphatidylcholine was 6-fold higher than the incorporation of AA into phosphatidylethanolamine. When vitamin E-deficient rat hearts were perfused with AA, there was a marked increase in incorporation of AA into both phosphatidylcholine and phosphatidylethanolamine compared to rats fed with a vitamin E supplemented diet. The result of this study suggests that vitamin E has a regulatory role in phospholipid biosynthesis in the mammalian heart.

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Year: 1985 PMID： 4010488 DOI： 10.1007/bf02534268

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

15 in total

1. A rapid method of total lipid extraction and purification.

Authors: E G BLIGH; W J DYER
Journal: Can J Biochem Physiol Date: 1959-08

2. Report of the American Institute of Nurtition ad hoc Committee on Standards for Nutritional Studies.

Authors:
Journal: J Nutr Date: 1977-07 Impact factor: 4.798

3. The effects of vitamin E and indomethacin on blood creatine phosphokinase and fatty acid composition of tissues from young rabbits.

Authors: A C Chan; C E Allen; P V Hegarty
Journal: Am J Clin Nutr Date: 1979-07 Impact factor: 7.045

4. Phosphatidylcholine biosynthesis in isolated hamster heart.

Authors: T A Zelinski; J D Savard; R Y Man; P C Choy
Journal: J Biol Chem Date: 1980-12-10 Impact factor: 5.157

5. Accumulation of unesterified arachidonic acid in ischemic canine myocardium. Relationship to a phosphatidylcholine deacylation-reacylation cycle and the depletion of membrane phospholipids.

Authors: K R Chien; A Han; A Sen; L M Buja; J T Willerson
Journal: Circ Res Date: 1984-03 Impact factor: 17.367

1. Vitamin E. deficiency increases the synthesis of platelet-activating factor (PAF) in rat polymorphonuclear leucocytes.

Authors: K Fukuzawa; Y Kurotori; A Tokumura; H Tsukatani
Journal: Lipids Date: 1989-03 Impact factor: 1.880

1 in total

Increased arachidonate incorporation in perfused heart phospholipids from vitamin E-deficient rats.

1. A rapid method of total lipid extraction and purification.

2. Report of the American Institute of Nurtition ad hoc Committee on Standards for Nutritional Studies.

3. The effects of vitamin E and indomethacin on blood creatine phosphokinase and fatty acid composition of tissues from young rabbits.

4. Phosphatidylcholine biosynthesis in isolated hamster heart.

5. Accumulation of unesterified arachidonic acid in ischemic canine myocardium. Relationship to a phosphatidylcholine deacylation-reacylation cycle and the depletion of membrane phospholipids.

6. The effect of antioxidant deficiency on tissue lipid composition in the rat. I. Gastrocnemius and quadriceps muscle.

7. Effects of vitamin E deficiency on the relative incorporation of 14C-arachidonate into platelet lipids of rabbits.

8. Phosphatidylethanolamine biosynthesis in isolated hamster heart.

9. Decreased prostacyclin synthesis in vitamin E-deficient rabbit aorta.

10. Generation of prostacyclin-like substance and lipid peroxidation in vitamin E-deficient rats.

1. Vitamin E. deficiency increases the synthesis of platelet-activating factor (PAF) in rat polymorphonuclear leucocytes.