| Literature DB >> 4010479 |
S Saeki, F Masugi, T Ogihara, A Otsuka, Y Kumahara, K Watanabe, K Tamura, A Akashi, A Kumagai.
Abstract
The direct cardiac action of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) was studied in isolated perfused guinea-pig heart preparations. PAF produced a fall in left ventricular pressure, decreases in the rate of rise of the left ventricular pressure (dp/dt) and coronary flow, but had no effect on heart rate. These results indicate that PAF is a cardiodepressant with inotropic selectivity and this effect on heart is blocked by CV-3988, a specific PAF antagonist.Entities:
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Year: 1985 PMID： 4010479 DOI： 10.1016/0024-3205(85)90502-8
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037