| Literature DB >> 4009611 |
J J Kaminski, J A Bristol, C Puchalski, R G Lovey, A J Elliott, H Guzik, D M Solomon, D J Conn, M S Domalski, S C Wong.
Abstract
A novel class of antiulcer agents, the substituted imidazo[1,2-a]pyridines, is described. The present compounds are not histamine (H2) receptor antagonists nor are they prostaglandin analogues, yet they exhibit both gastric antisecretory and cytoprotective properties. The mechanism of gastric antisecretory activity may involve inhibition of the H+/K+-ATPase enzyme. Structure-activity studies led to the identification of 3-(cyanomethyl)-2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine, SCH 28080 (27), which was selected for further development and clinical evaluation.Entities:
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Year: 1985 PMID： 4009611 DOI： 10.1021/jm00145a006
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446