Literature DB >> 400947

Glutamate dehydrogenase and aspartate aminotransferase in Trypanosoma cruzi.

J J Cazzulo1, S M Juan, E L Segura.   

Abstract

1. The cultured, epimastigote-form of Trypanosoma cruzi contains NADP-linked glutamate dehydrogenase (EC 1.4.1.4), with a molecular weight of about 280,000, similar to the enzyme from Plasmodium chabaudi and different from the enzymes from higher animal sources. 2. T. cruzi also contains aspartate aminotransferase (EC 2.6.1.1), with properties similar to those of the enzyme from mammals. 3. The concerted action of the transaminase and glutamate dehydrogenase might be responsible for the production of NH3 which characterizes the protein catabolism in T. cruzi.

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Year:  1977        PMID： 400947     DOI： 10.1016/0305-0491(77)90020-7

Source DB:  PubMed          Journal:  Comp Biochem Physiol B        ISSN： 0305-0491


  9 in total

1.  The rice Osmyb4 gene enhances tolerance to frost and improves germination under unfavourable conditions in transgenic barley plants.

Authors:  Alexandra Soltész; Attila Vágújfalvi; Fulvia Rizza; Ildikó Kerepesi; Gábor Galiba; Luigi Cattivelli; Immacolata Coraggio; Cristina Crosatti
Journal:  J Appl Genet       Date:  2012-01-14       Impact factor: 3.240

2.  Inhibition of the NADP-linked glutamate dehydrogenase from Trypanosoma cruzi by silver nitrate.

Authors:  S M Juan; E L Segura; J J Cazzulo
Journal:  Experientia       Date:  1979-09-15

3.  The NADP+-linked glutamate dehydrogenase from Trypanosoma cruzi: sequence, genomic organization and expression.

Authors:  P Barderi; O Campetella; A C Frasch; J A Santomé; U Hellman; U Pettersson; J J Cazzulo
Journal:  Biochem J       Date:  1998-03-01       Impact factor: 3.857

4.  Purification and partial structural and kinetic characterization of tyrosine aminotransferase from epimastigotes of Trypanosoma cruzi.

Authors:  M Montemartini; J A Santomé; J J Cazzulo; C Nowicki
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857

Review 5.  Intermediate metabolism in Trypanosoma cruzi.

Authors:  J J Cazzulo
Journal:  J Bioenerg Biomembr       Date:  1994-04       Impact factor: 2.945

6.  The Involvement of Glutamate Metabolism in the Resistance to Thermal, Nutritional, and Oxidative Stress in Trypanosoma cruzi.

Authors:  Anahí Magdaleno; Brian Suárez Mantilla; Sandra C Rocha; Elizabeth M F Pral; Ariel M Silber
Journal:  Enzyme Res       Date:  2011-04-10

7.  The glutamine synthetase of Trypanosoma cruzi is required for its resistance to ammonium accumulation and evasion of the parasitophorous vacuole during host-cell infection.

Authors:  Marcell Crispim; Flávia Silva Damasceno; Agustín Hernández; María Julia Barisón; Ismael Pretto Sauter; Raphael Souza Pavani; Alexandre Santos Moura; Elizabeth Mieko Furusho Pral; Mauro Cortez; Maria Carolina Elias; Ariel Mariano Silber
Journal:  PLoS Negl Trop Dis       Date:  2018-01-10

Review 8.  The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids.

Authors:  Letícia Marchese; Janaina de Freitas Nascimento; Flávia Silva Damasceno; Frédéric Bringaud; Paul A M Michels; Ariel Mariano Silber
Journal:  Pathogens       Date:  2018-04-01

9.  Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi.

Authors:  Isabel S Shiratsubaki; Xin Fang; Rodolpho O O Souza; Bernhard O Palsson; Ariel M Silber; Jair L Siqueira-Neto
Journal:  PLoS Negl Trop Dis       Date:  2020-10-06
  9 in total

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