| Literature DB >> 4008941 |
L J Charamella, C Meyer, G E Thompson, N V Dimitrov.
Abstract
This study investigated the effect of various clinically used chemotherapeutic agents on non-modulated and human alpha Interferon (IFN) modulated natural killer cell (NK) activity. The inhibitors of DNA synthesis, Adriamycin, Cis-Platinum, 5-Fluorouracil and Methotrexate, did not alter NK cell activity at comparable clinically used doses. Similarly, Vincristine and Vinblastine, which are antimitotic agents, did not affect the NK activity. Only inhibitors of RNA synthesis L-Asparaginase and Actinomycin D reduced non-modulated and IFN modulated NK cell activity.Entities:
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Year: 1985 PMID： 4008941 DOI： 10.3109/08923978509026469
Source DB: PubMed Journal: J Immunopharmacol ISSN： 0163-0571