Literature DB >> 4008328

Microbial phosphorylation of compactin (ML-236B) and related compounds.

A Endo, H Yamashita, H Naoki, T Iwashita, Y Mizukawa.   

Abstract

Several fungal strains were found to convert compactin (ML-236B) to 5'-phosphocompactic acid. The product was isolated by solvent extraction and column chromatography, and identified by IR, UV, 1H NMR, 13C NMR and 31P NMR spectroscopy. Related structures (monacolin K, L and X) were also transformed to their corresponding phosphorylated analogues. The products were re-converted back to respective parental compounds by treatment with alkaline phosphatase of calf intestine.

Entities:  

Mesh:

Substances:

Year:  1985        PMID: 4008328     DOI: 10.7164/antibiotics.38.328

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  2 in total

1.  Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist.

Authors:  Takahide Nishi; Shojiro Miyazaki; Toshiyasu Takemoto; Keisuke Suzuki; Yukiko Iio; Katsuyoshi Nakajima; Takashi Ohnuki; Yumi Kawase; Futoshi Nara; Shinichi Inaba; Takashi Izumi; Hiroshi Yuita; Keiko Oshima; Hiromi Doi; Ryotaku Inoue; Wataru Tomisato; Takashi Kagari; Takaichi Shimozato
Journal:  ACS Med Chem Lett       Date:  2011-03-02       Impact factor: 4.345

Review 2.  Chemistry, biochemistry, and pharmacology of HMG-CoA reductase inhibitors.

Authors:  A Endo
Journal:  Klin Wochenschr       Date:  1988-05-16
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.