Genetic control of in vivo IgE antibody production specific to Dermatophagoides farinae.

HLA population and family study were performed in individuals allergic to Dermatophagoides farinae. Manifestation of allergic symptoms and IgE production to D. farinae are possibly regulated in an autorecessive HLA-linked hereditary manner. This regulation may be focused on a lack of IgE Is gene. IgG and IgG4 antibody production to D. farinae may be regulated in the same manner as symptoms and IgE antibody production.