| Literature DB >> 4007891 |
J A Timbrell, B K Park, S J Harland.
Abstract
The effect of rifampicin on the metabolism of isoniazid in human volunteer subjects has been investigated. The urinary metabolites of isoniazid after a single dose and after six daily doses of isoniazid plus rifampicin were examined. The isoniazid-rifampicin combination clearly increased the ratio of urinary 6-beta-hydroxycortisol to 17-hydroxycorticosteroids, indicating that induction of the microsomal enzymes had occurred. However, no significant changes in the urinary metabolites of isoniazid were detected, and therefore it is not possible to predict the effect of rifampicin on isoniazid hepatotoxicity.Entities:
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Year: 1985 PMID： 4007891 DOI： 10.1177/096032718500400308
Source DB: PubMed Journal: Hum Toxicol ISSN： 0144-5952