Massive theophylline intoxication: effects of charcoal haemoperfusion on plasma and erythrocyte theophylline concentrations.

The results of a charcoal haemoperfusion on plasma and erythrocyte theophylline concentrations are described in a patient, intentionally intoxicated with a sustained-release theophylline formulation. It is demonstrated that the charcoal-filled Gambro Adsorba 300-C column is effective in removing theophylline. This effectiveness is based on pharmacokinetic parameters, which are presented. The necessity of measuring plasma and erythrocyte theophylline concentrations is outlined. Calculations based on plasma theophylline concentrations only can lead to an underestimation of the effectiveness.