tau-Crystallin from the turtle lens: purification and partial characterization.

A lens protein with a molecular mass near 46 000 daltons has been purified from the turtle lens. It is a monomeric protein which differs from other lens crystallins in its antigenicity, near-UV circular dichroism spectrum and amino acid composition. Like delta-crystallin, it has appreciable secondary structure (52% alpha-helix). This lens protein has been named tau-crystallin. tau-Crystallin cross-reacts with the novel 48 000 dalton protein identified recently in lenses of the sea lamprey. Although distinct, the possibility that tau-crystallin shares an ancestral relationship with delta-crystallin is discussed.