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Literature DB >> 4007042

Relationship between dose, blood level and haemodynamic response in patients with cirrhosis receiving propranolol.

Abstract

Fifty-two patients with cirrhosis receiving continuous administration of propranolol in doses reducing the heart rate by 25% were studied. The doses and plasma levels varied widely - 185 +/- 98 mg/day (mean +/- SD) and 208 +/- 153 ng/ml, respectively. These values were significantly correlated. No significant correlation was found between the dose of the drug or plasma level and the liver function tests. Although propranolol significantly decreased cardiac output and the hepatic venous pressure gradient, no correlation was found between drug dose or plasma level and these haemodynamic effects.

Entities: Chemical Disease Species

Mesh：

Substances：
Propranolol

Year: 1985 PMID： 4007042 DOI： 10.1007/bf00543337

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

10 in total

1. The disposition of propranolol. I. Elimination during oral absorption in man.

Authors: D G Shand; R E Rangno
Journal: Pharmacology Date: 1972 Impact factor: 2.547

2. Comparison of the antianginal efficacy of acebutolol and propranolol. A multicenter, randomized, double-blind placebo-controlled study.

Authors: R DiBianco; S N Singh; P M Shah; G C Newton; R R Miller; P Nahormek; R B Costello; A R Laddu; J S Gottdiener; R D Fletcher
Journal: Circulation Date: 1982-06 Impact factor: 29.690

1 in total

1. Pharmacodynamic and pharmacokinetic study of propranolol in patients with cirrhosis and portal hypertension.

Authors: P Calès; D Grasset; A Ravaud; C Meskens; M Blanc; J P Vinel; J Cotonat; J P Pascal
Journal: Br J Clin Pharmacol Date: 1989-06 Impact factor: 4.335

1 in total

Relationship between dose, blood level and haemodynamic response in patients with cirrhosis receiving propranolol.

1. The disposition of propranolol. I. Elimination during oral absorption in man.

2. Comparison of the antianginal efficacy of acebutolol and propranolol. A multicenter, randomized, double-blind placebo-controlled study.

3. Total and free propranolol levels in sensitive and resistant patients.

4. The influence of cirrhosis on steady-state blood concentrations of unbound propranolol after oral administration.

5. Mechanism for reduced drug clearance in patients with cirrhosis.

6. The effect of propranolol on portal hypertension in patients with cirrhosis: a hemodynamic study.

7. Sensitive high-pressure liquid chromatographic determination of propranolol in plasma.

Review 8. Clinical pharmacokinetics of propranolol.

9. Effects and plasma levels of propranolol and metoprolol in hyperthyroid patients.

10. Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: a controlled study.

1. Pharmacodynamic and pharmacokinetic study of propranolol in patients with cirrhosis and portal hypertension.