| Literature DB >> 4006972 |
P S Shepherd, C R Lazarus, R D Mistry, M N Maisey.
Abstract
A monoclonal antibody to human thyroglobulin was radiolabelled with 123I NaI and shown to be a stable and biologically active reagent in vivo. When injected intravenously into 12 patients with cancer of the thyroid on thyroxine-replacement therapy, 6 of the 12 patients had localization of the labelled antibody in tumour sites. These results were compared to 131I scans done on the same patients 1 month after stopping thyroxine. The biological half-life of the antibody in the blood was influenced by the levels of circulating thyroglobulin.Entities:
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Year: 1985 PMID： 4006972 DOI： 10.1007/bf00251298
Source DB: PubMed Journal: Eur J Nucl Med ISSN： 0340-6997