Literature DB >> 4006303

Progressive passive Heymann nephritis: induction of autologous antibodies to rat brush border by multiple injections of heterologous antiserum.

A Z Barabas, J Cornish, R Lannigan.   

Abstract

Multiple i.v. injection of a heterologous anti-rat kidney fraction 3 antiserum and guinea pig anti-rabbit F3 into rats produced a progressive immune complex glomerulonephritis. The kidney disease was characterized by diffuse beaded deposition of rat gammaglobulin along the glomerular capillaries and proteinuria. Gammaglobulin eluted from the kidneys reacted with the brush border region of normal rat kidney frozen sections. Control animals did not develop the progressive disease. It appears that multiple i.v. injections of the heterologous antisera are capable of inducing an autoimmune kidney disease which is similar to Heymann nephritis.

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Year:  1985        PMID： 4006303      PMCID： PMC1577038     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  13 in total

1.  Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. V. Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis.

Authors:  B J Van Damme; G J Fleuren; W W Bakker; R L Vernier; P J Hoedemaeker
Journal:  Lab Invest       Date:  1978-04       Impact factor: 5.662

2.  Induction of an autologous immune-complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody. I. Production of chronic progressive immune-complex glomerulonephritis.

Authors:  A Z Barabas; R Lannigan
Journal:  Br J Exp Pathol       Date:  1974-02

3.  Antibodies against the mitochondrial fraction of liver after toxic liver damage in rats.

Authors:  R N Pinckard; D M Weir
Journal:  Clin Exp Immunol       Date:  1966-01       Impact factor: 4.330

4.  Passive Heymann nephritis in the rat produced by a heterologous antibody to a heterologous kidney fraction 3 antigen.

Authors:  A Z Barabas; J Cornish; R Lannigan
Journal:  Br J Exp Pathol       Date:  1982-12

5.  Evaluation of homologous and isologous passive Heymann nephritis: influence on endogenous antibody production.

Authors:  C K Abrass; J McVay; R J Glassock
Journal:  J Immunol       Date:  1983-01       Impact factor: 5.422

6.  Induction of an autologous immune complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody. III. Long-term effects.

Authors:  A Z Barabas; R Lannigan
Journal:  Br J Exp Pathol       Date:  1975-06

7.  Experimental glomerulonephritis in the isolated perfused rat kidney.

Authors:  W G Couser; D R Steinmuller; M M Stilmant; D J Salant; L M Lowenstein
Journal:  J Clin Invest       Date:  1978-12       Impact factor: 14.808

8.  Progressive passive Heymann nephritis in the rat.

Authors:  A Z Barabas; N Boyd; J Cornish; R Lannigan
Journal:  Lab Invest       Date:  1982-10       Impact factor: 5.662

9.  Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions.

Authors:  W HEYMANN; D B HACKEL; S HARWOOD; S G WILSON; J L HUNTER
Journal:  Proc Soc Exp Biol Med       Date:  1959-04

10.  Passive transfer of autoimmune disease with isologous IgG1 and IgG2 antibodies to the tubular basement membrane in strain XIII guinea pigs: loss of self-tolerance induced by autoantibodies.

Authors:  C L Hall; R B Colvin; K Carey; R T McCluskey
Journal:  J Exp Med       Date:  1977-11-01       Impact factor: 14.307
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  1 in total

1.  Stimulation of circulating autoantibody levels in the rat with established progressive passive Heymann nephritis.

Authors:  A Z Barabas; J Cornish; R Lannigan
Journal:  Clin Exp Immunol       Date:  1986-07       Impact factor: 4.330
  1 in total

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