Literature DB >> 4005560

[1-14C]Octanoate: a fast functional marker of brain activity.

H Rowley, R C Collins.   

Abstract

[1-14C]Octanoate (OCTO) is rapidly extracted from blood and metabolized by brain. Up to 6 min following an intravenous pulse injection the autoradiographic pattern of brain labeling reflects differences in blood flow and energy metabolism. When animals are given OCTO during visual or somatosensory stimulation the autoradiograms reveal differential labeling of activated pathways. Studies can be performed in 7-20 s allowing fast labeling of functional brain anatomy.

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Year:  1985        PMID： 4005560     DOI： 10.1016/0006-8993(85)90486-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  4 in total

1.  Evaluation of the brain uptake properties of [1-11C]labeled hexanoate in anesthetized cats by means of positron emission tomography.

Authors:  Y Sakiyama; K Ishiwata; K Ishii; K Oda; H Toyama; S Ishii; H Nakayama; A Sato; M Senda
Journal:  Ann Nucl Med       Date:  1996-08       Impact factor: 2.668

2.  A brain uptake study of [1-(11)C]hexanoate in the mouse: the effect of hypoxia, starvation and substrate competition.

Authors:  K Ishiwata; K Ishii; K Ogawa; T Nozaki; M Senda
Journal:  Ann Nucl Med       Date:  1996-05       Impact factor: 2.668

Review 3.  Regulation of peripheral metabolism by substrate partitioning in the brain.

Authors:  Cesar Moreno; Linda Yang; Penny Dacks; Fumiko Isoda; Michael Poplawski; Charles V Mobbs
Journal:  Endocrinol Metab Clin North Am       Date:  2013-03       Impact factor: 4.741

4.  Brain uptake and metabolism of [1-11C]octanoate in rats: pharmacokinetic basis for its application as a radiopharmaceutical for studying brain fatty acid metabolism.

Authors:  Y Kuge; K Yajima; H Kawashima; H Yamazaki; N Hashimoto; Y Miyake
Journal:  Ann Nucl Med       Date:  1995-08       Impact factor: 2.668
  4 in total

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