Literature DB >> 4005485

Potentiation of morphine analgesia by caffeine.

A L Misra, R B Pontani, N L Vadlamani.   

Abstract

Significant potentiation of morphine (5 mg kg-1 s.c. or 1 mg kg-1 i.v.) analgesia (tail-withdrawal reflex at 55 degrees C) was observed in caffeine-treated (100 mg kg-1 i.p.) rats as compared to the control group and lower doses of caffeine (2mg kg-1 i.p.) did not show this effect. Potentiated analgesia was reversed by naloxone. Pharmacokinetic or dispositional factors appear to be involved in part in this potentiation.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 4005485      PMCID： PMC1987063          DOI： 10.1111/j.1476-5381.1985.tb17372.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Some effects of caffeine and aminophylline on the turnover of catecholamines in the brain.

Authors:  B Waldeck
Journal:  J Pharm Pharmacol       Date:  1971-11       Impact factor: 3.765

2.  Persistence of morphine in central nervous system of rats after a singel injection and its bearing on tolerance.

Authors:  A L Misra; C L Mitchell; L A Woods
Journal:  Nature       Date:  1971-07-02       Impact factor: 49.962

3.  Release of norepinephrine in the central nervous system by theophylline and caffeine.

Authors:  B A Berkowitz; J H Tarver; S Spector
Journal:  Eur J Pharmacol       Date:  1970-04       Impact factor: 4.432

Review 4.  Adenosine receptors in the central nervous system: relationship to the central actions of methylxanthines.

Authors:  J W Daly; R F Bruns; S H Snyder
Journal:  Life Sci       Date:  1981-05-11       Impact factor: 5.037

5.  Unit activity in medial thalamus: comparative effects of caffeine an amphetamine.

Authors:  D T Chou; J H Forde; K R Hirsh
Journal:  J Pharmacol Exp Ther       Date:  1980-06       Impact factor: 4.030

6.  Caffeine stimulates beta-endorphin release in blood but not in cerebrospinal fluid.

Authors:  M A Arnold; D B Carr; D M Togasaki; M C Pian; J B Martin
Journal:  Life Sci       Date:  1982-09-06       Impact factor: 5.037

7.  Caffeine as an analgesic adjuvant.

Authors:  E M Laska; A Sunshine; F Mueller; W B Elvers; C Siegel; A Rubin
Journal:  JAMA       Date:  1984-04-06       Impact factor: 56.272

8.  Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.

Authors:  R W BUTCHER; E W SUTHERLAND
Journal:  J Biol Chem       Date:  1962-04       Impact factor: 5.157

9.  Caffeine injection raises brain tryptophan level, but does not stimulate the rate of serotonin synthesis in rat brain.

Authors:  M H Fernstrom; C W Bazil; J D Fernstrom
Journal:  Life Sci       Date:  1984-09-17       Impact factor: 5.037
  9 in total
  3 in total

1.  Failure of coffee to inhibit the pharmacodynamic activity of morphine in vivo.

Authors:  O Strubelt; M Kaschube; G Zetler
Journal:  Experientia       Date:  1986-01-15

2.  Tramadol and Tramadol+Caffeine Synergism in the Rat Formalin Test Are Mediated by Central Opioid and Serotonergic Mechanisms.

Authors:  Norma Carrillo-Munguía; Ma Eva González-Trujano; Miguel Huerta; Xochitl Trujillo; M Irene Díaz-Reval
Journal:  Biomed Res Int       Date:  2015-06-04       Impact factor: 3.411

3.  Caffeine as an opioid analgesic adjuvant in fibromyalgia.

Authors:  J Ryan Scott; Afton L Hassett; Chad M Brummett; Richard E Harris; Daniel J Clauw; Steven E Harte
Journal:  J Pain Res       Date:  2017-07-28       Impact factor: 3.133
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.