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Literature DB >> 4005384

Testing the statistical certainty of a response to increasing doses of a drug.

Abstract

Experiments in which the treatments are composed of a series of doses of a compound and a zero dose control are often used in animal toxicity studies. A test procedure is proposed to assess trends in the response variable. The notion of a no-statistical-significance-of-trend (NOSTASOT) dose is introduced, and questions of multiplicity of statistical tests in this context are addressed.

Entities: Disease

Mesh：

Substances：
Serum Albumin

Year: 1985 PMID： 4005384

Source DB: PubMed Journal: Biometrics ISSN： 0006-341X Impact factor: 2.571

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Cited

44 in total

1. Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection.

Authors: Tomokazu Yoshinaga; Masanori Kobayashi; Takahiro Seki; Shigeru Miki; Chiaki Wakasa-Morimoto; Akemi Suyama-Kagitani; Shinobu Kawauchi-Miki; Teruhiko Taishi; Takashi Kawasuji; Brian A Johns; Mark R Underwood; Edward P Garvey; Akihiko Sato; Tamio Fujiwara
Journal: Antimicrob Agents Chemother Date: 2014-11-03 Impact factor: 5.191

Review 2. Statistical issues in longitudinal data analysis for treatment efficacy studies in the biomedical sciences.

Authors: Chunyan Liu; Timothy P Cripe; Mi-Ok Kim
Journal: Mol Ther Date: 2010-06-29 Impact factor: 11.454

3. In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.

Authors: Masanori Kobayashi; Tomokazu Yoshinaga; Takahiro Seki; Chiaki Wakasa-Morimoto; Kevin W Brown; Robert Ferris; Scott A Foster; Richard J Hazen; Shigeru Miki; Akemi Suyama-Kagitani; Shinobu Kawauchi-Miki; Teruhiko Taishi; Takashi Kawasuji; Brian A Johns; Mark R Underwood; Edward P Garvey; Akihiko Sato; Tamio Fujiwara
Journal: Antimicrob Agents Chemother Date: 2010-11-29 Impact factor: 5.191

4. A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long-acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion.

Authors: R H Lustig; F Greenway; P Velasquez-Mieyer; D Heimburger; D Schumacher; D Smith; W Smith; N Soler; G Warsi; W Berg; J Maloney; J Benedetto; W Zhu; J Hohneker
Journal: Int J Obes (Lond) Date: 2006-02 Impact factor: 5.095

Testing the statistical certainty of a response to increasing doses of a drug.

1. Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection.

Review 2. Statistical issues in longitudinal data analysis for treatment efficacy studies in the biomedical sciences.

3. In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.

4. A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long-acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion.

Review 5. Evaluation of methods for estimating time to steady state with examples from phase 1 studies.

6. Quantitative grip strength assessment as a means of evaluating muscle relaxation in mice.

7. Serum linoleic acid status as a clinical indicator of essential fatty acid status in children with cystic fibrosis.

8. In vivo diffusion tensor imaging and histopathology of the fimbria-fornix in temporal lobe epilepsy.

9. Topiramate in migraine prophylaxis--results from a placebo-controlled trial with propranolol as an active control.

10. The effect of shortening history on isometric and dynamic muscle function.