Literature DB >> 4005123

Gastrointestinal transit of Oros drug delivery systems in healthy volunteers: a short report.

V A John, P A Shotton, J Moppert, W Theobald.   

Abstract

Transit times for oxprenolol and metoprolol Oros drug delivery systems through the gastrointestinal tract have been measured in 35 individuals in six separate studies. A total of 45 systems were recovered in a median time of 27.4 h; individual transit times varied from 5.1 to 58.3 h. The residual amount of drug in recovered systems was inversely related to transit time and corresponded closely with the amount estimated from in vitro dissolution profiles.

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Year:  1985        PMID： 4005123      PMCID： PMC1463756          DOI： 10.1111/j.1365-2125.1985.tb02763.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  8 in total

1.  Absorption and excretions studies on tetracycline.

Authors:  M H PINDELL; K M CULL; K M DORAN; H L DICKISON
Journal:  J Pharmacol Exp Ther       Date:  1959-04       Impact factor: 4.030

2.  A ne method for studying gut transit times using radioopaque markers.

Authors:  J M Hinton; J E Lennard-Jones; A C Young
Journal:  Gut       Date:  1969-10       Impact factor: 23.059

3.  Influence of site of drug delivery on the systemic availability of metoprolol: comparison of intragastric infusion and 14/190 Oros administration.

Authors:  S J Warrington; S P Barclay; V A John; P A Shotton; H M Wardle; W Good
Journal:  Br J Clin Pharmacol       Date:  1985       Impact factor: 4.335

4.  The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine.

Authors:  G Vantrappen; J Janssens; J Hellemans; Y Ghoos
Journal:  J Clin Invest       Date:  1977-06       Impact factor: 14.808

5.  Usefulness of chromic oxide as an internal standard for balance studies in formula-fed patients and for assessment of colonic function.

Authors:  J Davignon; W J Simmonds; E H Ahrens
Journal:  J Clin Invest       Date:  1968-01       Impact factor: 14.808

6.  Measurement of the mean transit time of dietary residue through the human gut.

Authors:  J H Cummings; D J Jenkins; H S Wiggins
Journal:  Gut       Date:  1976-03       Impact factor: 23.059

7.  Factors controlling colonic motility: colonic pressures and transit after meals in patients with total gastrectomy, pernicious anaemia or duodenal ulcer.

Authors:  D J Holdstock; J J Misiewicz
Journal:  Gut       Date:  1970-02       Impact factor: 23.059

8.  Pharmacokinetic investigation of the absorption of oxprenolol from Oros delivery systems in healthy volunteers: comparison of in vivo and in vitro drug release.

Authors:  I D Bradbrook; V A John; P J Morrison; H J Rogers; R G Spector
Journal:  Br J Clin Pharmacol       Date:  1985       Impact factor: 4.335
  8 in total
  10 in total

Review 1.  Pharmacokinetic variability of long-acting stimulants in the treatment of children and adults with attention-deficit hyperactivity disorder.

Authors:  James C Ermer; Ben A Adeyi; Michael L Pucci
Journal:  CNS Drugs       Date:  2010-12       Impact factor: 5.749

Review 2.  Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms.

Authors:  J B Dressman; G L Amidon; C Reppas; V P Shah
Journal:  Pharm Res       Date:  1998-01       Impact factor: 4.200

3.  Relationship between the rate of appearance of oxprenolol in the systemic circulation and the location of an oxprenolol Oros 16/260 drug delivery system within the gastrointestinal tract as determined by scintigraphy.

Authors:  S S Davis; N Washington; G D Parr; A H Short; V A John; P Lloyd; S M Walker
Journal:  Br J Clin Pharmacol       Date:  1988-10       Impact factor: 4.335

4.  Comparison of single-dose pharmacokinetic and pharmacodynamic properties of two metoprolol Oros systems with different initial zero-order release rates.

Authors:  S J Warrington; S P Barclay; V A John; P A Shotton; W Good
Journal:  Br J Clin Pharmacol       Date:  1985       Impact factor: 4.335

5.  Gastrointestinal transit and systemic absorption of captopril from a pulsed-release formulation.

Authors:  I R Wilding; S S Davis; M Bakhshaee; H N Stevens; R A Sparrow; J Brennan
Journal:  Pharm Res       Date:  1992-05       Impact factor: 4.200

6.  Absorption, gastrointestinal transit, and tablet erosion of felodipine extended-release (ER) tablets.

Authors:  B Abrahamsson; M Alpsten; M Hugosson; U E Jonsson; M Sundgren; A Svenheden; J Tölli
Journal:  Pharm Res       Date:  1993-05       Impact factor: 4.200

7.  Relationship between systemic drug absorption and gastrointestinal transit after the simultaneous oral administration of carbamazepine as a controlled-release system and as a suspension of 15N-labelled drug to healthy volunteers.

Authors:  I R Wilding; S S Davis; J G Hardy; C S Robertson; V A John; M L Powell; M Leal; P Lloyd; S M Walker
Journal:  Br J Clin Pharmacol       Date:  1991-11       Impact factor: 4.335

Review 8.  The nifedipine gastrointestinal therapeutic system (GITS). Evaluation of pharmaceutical, pharmacokinetic and pharmacological properties.

Authors:  J S Grundy; R T Foster
Journal:  Clin Pharmacokinet       Date:  1996-01       Impact factor: 6.447

Review 9.  Controlled release metoprolol formulations. A review of their pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and ischaemic heart disease.

Authors:  G L Plosker; S P Clissold
Journal:  Drugs       Date:  1992-03       Impact factor: 9.546

10.  Stable isotope methodology for studying the performance of metoprolol Oros tablets in comparison to conventional and slow release formulations.

Authors:  J Richard; J M Cardot; J Godbillon
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1994 Oct-Dec       Impact factor: 2.441
  10 in total

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