Literature DB >> 4004815

Effects of phorbol esters on alpha 1-adrenergic-mediated and glucagon-mediated actions in isolated rat hepatocytes.

J A García-Sáinz, F Mendlovic, M A Martínez-Olmedo.   

Abstract

Phorbol 12-myristate 13-acetate (PMA) inhibited the stimulation of ureogenesis produced by adrenaline, but produced a minimal displacement to the right of the dose-response curve for glucagon. However, PMA diminished the accumulation of cyclic AMP induced by glucagon. Dissociation between the cyclic AMP concentrations and the metabolic effects induced by glucagon is evidenced in the presence of phorbol esters.

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Year:  1985        PMID： 4004815      PMCID： PMC1144981          DOI： 10.1042/bj2280277

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  21 in total

1.  Lack of correlation between hormonal effects on cyclic AMP and glycogenolysis in rat liver.

Authors:  F Okajima; M Ui
Journal:  Arch Biochem Biophys       Date:  1976-08       Impact factor: 4.013

2.  Angiotensin II inhibits the accumulation of cyclic AMP produced by glucagon but not its metabolic effects.

Authors:  R J Cárdenas-Tanús; J Huerta-Bahena; J A García-Sáinz
Journal:  FEBS Lett       Date:  1982-06-21       Impact factor: 4.124

3.  Phorbol esters inhibit alpha 1 adrenergic stimulation of glycogenolysis in isolated rat hepatocytes.

Authors:  S Corvera; J A García-Sáinz
Journal:  Biochem Biophys Res Commun       Date:  1984-03-30       Impact factor: 3.575

4.  Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transferrin membrane receptors in HL60 cells.

Authors:  W S May; S Jacobs; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

5.  Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

Authors:  M Castagna; Y Takai; K Kaibuchi; K Sano; U Kikkawa; Y Nishizuka
Journal:  J Biol Chem       Date:  1982-07-10       Impact factor: 5.157

6.  Activation of protein kinase and glycogen phosphorylase in isolated rat liver cells by glucagon and catecholamines.

Authors:  M J Birnbaum; J N Fain
Journal:  J Biol Chem       Date:  1977-01-25       Impact factor: 5.157

7.  Tumor-promoting phorbol diesters mediate phosphorylation of the epidermal growth factor receptor.

Authors:  R J Davis; M P Czech
Journal:  J Biol Chem       Date:  1984-07-10       Impact factor: 5.157

8.  Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

Authors:  U Kikkawa; Y Takai; Y Tanaka; R Miyake; Y Nishizuka
Journal:  J Biol Chem       Date:  1983-10-10       Impact factor: 5.157

9.  Alpha 1-adrenoceptor activation stimulates ureogenesis in rat hepatocytes.

Authors:  S Corvera; J A García-Sáinz
Journal:  Eur J Pharmacol       Date:  1981-07-10       Impact factor: 4.432

10.  High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.

Authors:  M N Berry; D S Friend
Journal:  J Cell Biol       Date:  1969-12       Impact factor: 10.539
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  10 in total

1.  Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values.

Authors:  G J Murphy; M D Houslay
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

2.  Co-transfection with protein kinase D confers phorbol-ester-mediated inhibition on glucagon-stimulated cAMP accumulation in COS cells transfected to overexpress glucagon receptors.

Authors:  E S Tobias; E Rozengurt; J M Connell; M D Houslay
Journal:  Biochem J       Date:  1997-09-01       Impact factor: 3.857

Review 3.  Drug-induced dementia. Incidence, management and prevention.

Authors:  J M Starr; L J Whalley
Journal:  Drug Saf       Date:  1994-11       Impact factor: 5.606

4.  The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism.

Authors:  G J Murphy; V J Hruby; D Trivedi; M J Wakelam; M D Houslay
Journal:  Biochem J       Date:  1987-04-01       Impact factor: 3.857

5.  4 beta-Phorbol 12-myristate 13-acetate attenuates the glucagon-induced increase in cytoplasmic free Ca2+ concentration in isolated rat hepatocytes.

Authors:  J M Staddon; R G Hansford
Journal:  Biochem J       Date:  1986-09-15       Impact factor: 3.857

6.  Stimulation of phosphoinositide metabolism in hamster brown adipocytes exposed to alpha 1-adrenergic agents and its inhibition with phorbol esters.

Authors:  R J Schimmel; D Dzierzanowski; M E Elliott; T W Honeyman
Journal:  Biochem J       Date:  1986-06-15       Impact factor: 3.857

7.  Interaction between the two signal transduction systems of the histamine H2 receptor: desensitizing and sensitizing effects of histamine stimulation on histamine-dependent cAMP production in Chinese hamster ovary cells.

Authors:  Y Fukushima; T Asano; H Katagiri; M Aihara; T Saitoh; M Anai; M Funaki; T Ogihara; K Inukai; N Matsuhashi; Y Oka; Y Yazaki; K Sugano
Journal:  Biochem J       Date:  1996-11-15       Impact factor: 3.857

8.  Modulation of glucagon-induced glucose production by dexfenfluramine in rat hepatocytes.

Authors:  B Comte; A Romanelli; S Tchu; G van de Werve
Journal:  Biochem J       Date:  1995-08-15       Impact factor: 3.857

9.  The glucagon-induced activation of pyruvate dehydrogenase in hepatocytes is diminished by 4 beta-phorbol 12-myristate 13-acetate. A role for cytoplasmic Ca2+ in dehydrogenase regulation.

Authors:  J M Staddon; R G Hansford
Journal:  Biochem J       Date:  1987-02-01       Impact factor: 3.857

Review 10.  Calcium: its modulation in liver by cross-talk between the actions of glucagon and calcium-mobilizing agonists.

Authors:  F L Bygrave; A Benedetti
Journal:  Biochem J       Date:  1993-11-15       Impact factor: 3.857
  10 in total

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