Literature DB >> 4004198

Effects of urinary pH on renal interactions between probenecid and cefsulodin in rabbits.

F Dromer, A Contrepois, N Brion, C Klein, C Carbon.   

Abstract

The effect of urinary pH on renal interaction of cefsulodin and probenecid was tested in rabbits. Probenecid was reabsorbed in acidic urine (fractional excretion [FE] = 8 +/- 4%) and secreted in alkaline urine (FE = 492 +/- 258%). Renal excretion of cefsulodin alone was not affected by the urinary pH (FE = ca. 100%). In acidic urine, probenecid significantly reduced tubular secretion of cefsulodin (FE = 74 +/- 8%). An inverse pattern was observed in alkaline urine (FE = 122 +/- 18%).

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 4004198      PMCID： PMC180119          DOI： 10.1128/AAC.27.4.660

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  The physiological disposition of probenecid, including renal clearance, in man, studied by an improved method for its estimation in biological material.

Authors:  P G DAYTON; T F YU; W CHEN; L BERGER; L A WEST; A B GUTMAN
Journal:  J Pharmacol Exp Ther       Date:  1963-06       Impact factor: 4.030

2.  'Benemid,' p-(di-n-propylsulfamyl)-benzoic acid; its renal affinity and its elimination.

Authors:  K H BEYER; H F RUSSO; E K TILLSON; A K MILLER; W F VERWEY; S R GASS
Journal:  Am J Physiol       Date:  1951-09

3.  Comparative multiple-dose pharmacokinetics of cefotaxime, moxalactam, and ceftazidime.

Authors:  R Lüthy; J Blaser; A Bonetti; H Simmen; R Wise; W Siegenthaler
Journal:  Antimicrob Agents Chemother       Date:  1981-11       Impact factor: 5.191

4.  Renal excretion of urate: factors determining the actions of drugs.

Authors:  F Roch-Ramel; I M Weiner
Journal:  Kidney Int       Date:  1980-11       Impact factor: 10.612

5.  Effects of phenylbutazone on extravascular diffusion, protein binding and urinary excretion of cefazolin in rabbits.

Authors:  C Carbon; A Contrepois; Y Nivoche; M Grandjean; S Decourt; N P Chau
Journal:  J Pharmacol Exp Ther       Date:  1981-08       Impact factor: 4.030

6.  Metabolic alkalosis in the rat. Evidence that reduced glomerular filtration rather than enhanced tubular bicarbonate reabsorption is responsible for maintaining the alkalotic state.

Authors:  M G Cogan; F Y Liu
Journal:  J Clin Invest       Date:  1983-05       Impact factor: 14.808

Review 7.  Clinical pharmacokinetics of probenecid.

Authors:  R F Cunningham; Z H Israili; P G Dayton
Journal:  Clin Pharmacokinet       Date:  1981 Mar-Apr       Impact factor: 6.447

8.  Probenecid: an unexplained effect on cephalosporin pharmacology.

Authors:  P G Welling; S Dean; A Selen; M J Kendall; R Wise
Journal:  Br J Clin Pharmacol       Date:  1979-11       Impact factor: 4.335

9.  Renal disposition of moxalactam in experimental animals as revealed by stop-flow analysis.

Authors:  J Shimada; T Yamaji; T Miyahara; Y Ueda; T Kawabata; K Sugeno; T Yoshida; M Nakamura
Journal:  Antimicrob Agents Chemother       Date:  1983-01       Impact factor: 5.191

10.  Renal disposition of ceftazidime illustrated by interferences by probenecid, furosemide, and indomethacin in rabbits.

Authors:  C Carbon; F Dromer; N Brion; A C Cremieux; A Contrepois
Journal:  Antimicrob Agents Chemother       Date:  1984-09       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.