Reduction of plasma norepinephrine levels in response to brief coronary occlusion in experimental dogs.

Although an increased plasma norepinephrine (NE) level is sometimes observed during angina pectoris, it is difficult to say whether sympathetic overflow is its cause. The left anterior descending coronary artery was occluded by intracoronary balloon for 3 minutes in 12 closed-chest anesthetized dogs. During occlusion, heart rate did not change but aortic pressure slightly decreased. Occlusion caused a significant reduction in both NE levels in the aorta (177 +/- 17 to 134 +/- 16 pg/ml, p less than 0.01) and in the great cardiac vein (GCV) 296 +/- 44 to 249 +/- 44 pg/ml, p less than 0.01). After surgical vagotomy, the occlusion increased NE levels in the aorta (227 +/- 44 to 278 +/- 43 pg/ml, p less than 0.01) and in GCV (384 +/- 76 to 444 +/- 81 pg/ml, p less than 0.01), showing the release of vagal inhibition. These results may be applicable to patients with transient anterior myocardial ischemia; if plasma NE increases without marked hemodynamic changes, it is suggested that the sympathetic overflow is not a result but a possible cause of the ischemia.