Literature DB >> 4000901

Research in the Division of Toxicology. The importance of reactive intermediates of drug biotransformation in drug toxicity.

G J Mulder.   

Abstract

Within the Center for Bio-Pharmaceutical Sciences research on toxicology has its main object in toxification and detoxification of xenobiotics. The pharmacokinetics of sulfation, glucuronidation and other conjugation reactions is studied. Conjugation may prevent tissue damage that is caused by covalent binding of reactive intermediates. Systems for testing the toxicity of such intermediates are being developed, and a similar screening programme is pursued for elucidating the involvement of reactive intermediates in carcinogenesis.

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Year:  1985        PMID： 4000901     DOI： 10.1007/bf02106130

Source DB:  PubMed          Journal:  Pharm Weekbl Sci        ISSN： 0167-6555


  13 in total

1.  The metabolic formation of N-acetyl-S-2-hydroxyethyl-L-cysteine from tetradeutero-1,2-dibromoethane. relative importance of oxidation and glutathione conjugation in vivo.

Authors:  P J van Bladeren; D D Breimer; J A van Huijgevoort; N P Vermeulen; A van der Gen
Journal:  Biochem Pharmacol       Date:  1981-09-01       Impact factor: 5.858

2.  Inhibition of sulfate conjugation of N-hydroxy-2-acetylaminofluorene in isolated perfused rat liver and in the rat in vivo by pentachlorophenol and low sulfate.

Authors:  J H Meerman; A B van Doorn; G J Mulder
Journal:  Cancer Res       Date:  1980-10       Impact factor: 12.701

3.  Extrahepatic sulfation and glucuronidation in the rat in vivo. Determination of the hepatic extraction ratio of harmol and the extrahepatic contribution to harmol conjugation.

Authors:  G J Mulder; J G Weitering; E Scholtens; J R Dawson; K S Pang
Journal:  Biochem Pharmacol       Date:  1984-10-01       Impact factor: 5.858

4.  The relation between the structure of vicinal dihalogen compounds and their mutagenic activation via conjugation to glutathione.

Authors:  P J van Bladeren; D D Breimer; G M Rotteveel-Smijs; P de Knijff; G R Mohn; B van Meeteren-Wälchli; W Buijs; A van der Gen
Journal:  Carcinogenesis       Date:  1981       Impact factor: 4.944

5.  Prevention of the hepatotoxic action of N-hydroxy-2-acetylaminofluorene in the rat by inhibition of N-O-sulfation by pentachlorophenol.

Authors:  J H Meerman; G J Mulder
Journal:  Life Sci       Date:  1981-05-21       Impact factor: 5.037

6.  D-cysteine as a selective precursor for inorganic sulfate in the rat in vivo. Effect of D-cysteine on the sulfation of harmol.

Authors:  E J Glazenburg; I M Jekel-Halsema; A Baranczyk-Kuzma; K R Krijgsheld; G J Mulder
Journal:  Biochem Pharmacol       Date:  1984-02-15       Impact factor: 5.858

7.  Inhibition of acetaminophen sulfation by 2,6-dichloro-4-nitrophenol in the perfused rat liver preparation. Lack of a compensatory increase of glucuronidation.

Authors:  S Fayz; W F Cherry; J R Dawson; G J Mulder; K S Pang
Journal:  Drug Metab Dispos       Date:  1984 May-Jun       Impact factor: 3.922

8.  Reaction of mutagenic phenacetin metabolites with glutathione and DNA. Possible implications for toxicity.

Authors:  G J Mulder; F F Kadlubar; J B Mays; J A Hinson
Journal:  Mol Pharmacol       Date:  1984-09       Impact factor: 4.436

9.  Use of pentachlorophenol as long-term inhibitor of sulfation of phenols and hydroxamic acids in the rat in vivo.

Authors:  J H Meerman; H M Sterenborg; G J Mulder
Journal:  Biochem Pharmacol       Date:  1983-05-15       Impact factor: 5.858

10.  Inhibition of glutathione efflux in the recirculating rat liver perfusion by cysteine but not by oxothiazolidine carboxylate, an intracellular cysteine precursor.

Authors:  E J Glazenburg; J E Bruggink; K Wolters-Keulemans; G J Mulder
Journal:  FEBS Lett       Date:  1984-12-10       Impact factor: 4.124
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