Literature DB >> 3999002

Solubilization by cosolvents I: organic solutes in propylene glycol-water mixtures.

S H Yalkowsky, J T Rubino.   

Abstract

An equation describing solubilization in aqueous systems by cosolvents was developed by treating a mixed solvent as a linear combination of its components. This equation can successfully explain both the exponential increases and the exponential decreases in aqueous solubility that are frequently observed with the addition of cosolvent. It also provides a means of estimating to what extent a particular drug can be solubilized and how much cosolvent would be required to accomplish a particular degree of solubilization.

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Year:  1985        PMID： 3999002     DOI： 10.1002/jps.2600740410

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  15 in total

1.  Solubility of pioglitazone hydrochloride in binary and ternary mixtures of water, propylene glycol, and polyethylene glycols 200, 400, and 600 at 298.2 k.

Authors:  Abolghasem Jouyban; Shahla Soltanpour
Journal:  AAPS PharmSciTech       Date:  2010-11-30       Impact factor: 3.246

2.  Butyl-p-aminobenzoate. Preparation, characterization and quality control of a suspension injection for epidural analgesia.

Authors:  R J Grouls; E W Ackerman; E J Machielsen; H H Korsten
Journal:  Pharm Weekbl Sci       Date:  1991-02-22

3.  Use of an in vitro model for the assessment of muscle damage from intramuscular injections: in vitro-in vivo correlation and predictability with mixed solvent systems.

Authors:  G A Brazeau; H L Fung
Journal:  Pharm Res       Date:  1989-09       Impact factor: 4.200

4.  Effect of concentration and degree of saturation of topical fluocinonide formulations on in vitro membrane transport and in vivo availability on human skin.

Authors:  F P Schwarb; G Imanidis; E W Smith; J M Haigh; C Surber
Journal:  Pharm Res       Date:  1999-06       Impact factor: 4.200

5.  Cosolvency and cosolvent polarity.

Authors:  J T Rubino; S H Yalkowsky
Journal:  Pharm Res       Date:  1987-06       Impact factor: 4.200

6.  Cosolvency and deviations from log-linear solubilization.

Authors:  J T Rubino; S H Yalkowsky
Journal:  Pharm Res       Date:  1987-06       Impact factor: 4.200

7.  Improving solubility and oral bioavailability of a novel antimalarial prodrug: comparing spray-dried dispersions with self-emulsifying drug delivery systems.

Authors:  Suresh Potharaju; Shravan Kumar Mutyam; Mingtao Liu; Carol Green; Lisa Frueh; Aaron Nilsen; Sovitj Pou; Rolf Winter; Michael K Riscoe; Gita Shankar
Journal:  Pharm Dev Technol       Date:  2020-02-12       Impact factor: 3.133

8.  P-glycoprotein Restricts Ocular Penetration of Loperamide across the Blood-Ocular Barriers: a Comparative Study in Mdr1a Knock-out and Wild Type Sprague Dawley Rats.

Authors:  Akshaya Tatke; Karthik Yadav Janga; Bharathi Avula; XiangDi Wang; Monica M Jablonski; Ikhlas A Khan; Soumyajit Majumdar
Journal:  AAPS PharmSciTech       Date:  2018-03-08       Impact factor: 3.246

9.  Micellar solubilization of timobesone acetate in aqueous and aqueous propylene glycol solutions of nonionic surfactants.

Authors:  J T Ong; E Manoukian
Journal:  Pharm Res       Date:  1988-11       Impact factor: 4.200

10.  Solubilization of cyclosporin A.

Authors:  Y Ran; L Zhao; Q Xu; S H Yalkowsky
Journal:  AAPS PharmSciTech       Date:  2001-01-18       Impact factor: 3.246
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