Literature DB >> 3997669

Biosynthesis of chrysomycins A and B. Origin of the chromophore.

G T Carter, A A Fantini, J C James, D B Borders, R J White.   

Abstract

The biosynthetic origin of the carbon atoms in the chromophores of chrysomycins A and B was investigated in feeding experiments using 13C labeled acetates and propionate. A biosynthetic scheme is proposed involving the condensation and rearrangement of a decaketide intermediate which contains either propionate (chrysomycin A) or acetate (chrysomycin B) as the chain initiator.

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Year:  1985        PMID: 3997669     DOI: 10.7164/antibiotics.38.242

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  7 in total

1.  A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.

Authors:  Eita Sasaki; Yasushi Ogasawara; Hung-Wen Liu
Journal:  J Am Chem Soc       Date:  2010-06-02       Impact factor: 15.419

2.  The crystal structure and mechanism of an unusual oxidoreductase, GilR, involved in gilvocarcin V biosynthesis.

Authors:  Nicholas Noinaj; Mary A Bosserman; M Alexandra Schickli; Grzegorz Piszczek; Madan K Kharel; Pallab Pahari; Susan K Buchanan; Jürgen Rohr
Journal:  J Biol Chem       Date:  2011-05-10       Impact factor: 5.157

3.  Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters.

Authors:  Madan K Kharel; S Eric Nybo; Micah D Shepherd; Jürgen Rohr
Journal:  Chembiochem       Date:  2010-03-01       Impact factor: 3.164

Review 4.  Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.

Authors:  Madan K Kharel; Jürgen Rohr
Journal:  Curr Opin Chem Biol       Date:  2012-03-30       Impact factor: 8.822

5.  Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis.

Authors:  Pallab Pahari; Madan K Kharel; Micah D Shepherd; Steven G van Lanen; Jürgen Rohr
Journal:  Angew Chem Int Ed Engl       Date:  2011-12-23       Impact factor: 15.336

6.  Comprehensive Genomic Analysis of Marine Strain Streptomyces sp. 891, an Excellent Producer of Chrysomycin A with Therapeutic Potential.

Authors:  Xu Hu; Yuqi Tang; Yuanyuan Liu; Xinwei Pei; Ziwei Huang; Fuhang Song; Huawei Zhang
Journal:  Mar Drugs       Date:  2022-04-24       Impact factor: 6.085

7.  GilR, an unusual lactone-forming enzyme involved in gilvocarcin biosynthesis.

Authors:  Madan Kumar Kharel; Pallab Pahari; Hui Lian; Jürgen Rohr
Journal:  Chembiochem       Date:  2009-05-25       Impact factor: 3.164

  7 in total

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