Literature DB >> 3996594

Human brain fibroblast growth factor. Isolation and partial chemical characterization.

P Böhlen, F Esch, A Baird, K L Jones, D Gospodarowicz.   

Abstract

Fibroblast growth factor (FGF) has been purified to homogeneity from human brain by a procedure involving salt precipitation, cation-exchange chromatography, Heparin-Sepharose affinity chromatography and reverse-phase HPLC. Isolation was monitored by radioimmunoassay and/or by testing column fractions for their capacity to stimulate the proliferation of vascular endothelial cells in vitro. The amino-terminal sequence of human brain FGF was determined as Pro-Ala-Leu-Pro-Glu-Asp-Gly-Gly-Ser-Gly-Ala-Phe-Pro-. This sequence is identical to that of the amino-terminal region of bovine FGF. Additional evidence, including amino acid composition, chromatographic retention behavior, and immunoreactivity suggest that the human and bovine mitogens are very similar in structure.

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Year:  1985        PMID： 3996594     DOI： 10.1016/0014-5793(85)80765-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.

Authors:  F Esch; A Baird; N Ling; N Ueno; F Hill; L Denoroy; R Klepper; D Gospodarowicz; P Böhlen; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205

2.  Purification from a human hepatoma cell line of a basic fibroblast growth factor-like molecule that stimulates capillary endothelial cell plasminogen activator production, DNA synthesis, and migration.

Authors:  M Presta; D Moscatelli; J Joseph-Silverstein; D B Rifkin
Journal:  Mol Cell Biol       Date:  1986-11       Impact factor: 4.272

3.  Fibroblast growth factors: an epigenetic mechanism of broad spectrum resistance to anticancer drugs.

Authors:  S Song; M G Wientjes; Y Gan; J L Au
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-18       Impact factor: 11.205

Review 4.  Neurotrophic factors for the investigation and treatment of movement disorders.

Authors:  Justo Garcia De Yébenes; Marina Sánchez; Maria Angeles Mena
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.911

5.  Mr 25,000 heparin-binding protein from guinea pig brain is a high molecular weight form of basic fibroblast growth factor.

Authors:  D Moscatelli; J Joseph-Silverstein; R Manejias; D B Rifkin
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

6.  Distribution of basic fibroblast growth factor in the 18-day rat fetus: localization in the basement membranes of diverse tissues.

Authors:  A M Gonzalez; M Buscaglia; M Ong; A Baird
Journal:  J Cell Biol       Date:  1990-03       Impact factor: 10.539

7.  Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

Authors:  J A Abraham; J L Whang; A Tumolo; A Mergia; J Friedman; D Gospodarowicz; J C Fiddes
Journal:  EMBO J       Date:  1986-10       Impact factor: 11.598

8.  Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor.

Authors:  M Klagsbrun; J Sasse; R Sullivan; J A Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205
  8 in total

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