Literature DB >> 3996545

The potency of heparin-like activity of glycosaminoglycans released by human endothelial cells in culture.

K Shimada, I Kusumoto, T Ozawa.   

Abstract

Glycosaminoglycans isolated from culture medium conditioned by human endothelial cells showed heparin-like anti-thrombin III cofactor activity measured by Xa inhibition. Their activity was relatively weak, 0.1% of the potency of heparin, but was approximately 5-fold more potent than that of glycosaminoglycans derived from vascular smooth muscle cells.

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Year:  1985        PMID: 3996545     DOI: 10.1007/bf02007713

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  10 in total

1.  Distribution of acidic glycosaminoglycans in the intima, media and adventitia of bovine aorta and their anticoagulant properties.

Authors:  K Murata; K Nakazawa; A Hamai
Journal:  Atherosclerosis       Date:  1975 Jan-Feb       Impact factor: 5.162

2.  A modified uronic acid carbazole reaction.

Authors:  T BITTER; H M MUIR
Journal:  Anal Biochem       Date:  1962-10       Impact factor: 3.365

3.  Assay of heparin in plasma using a chromogenic substrate for activated factor X.

Authors:  A N Teien; M Lie; U Abildgaard
Journal:  Thromb Res       Date:  1976-03       Impact factor: 3.944

4.  Anticoagulant action of heparin.

Authors:  P S Damus; M Hicks; R D Rosenberg
Journal:  Nature       Date:  1973-12-07       Impact factor: 49.962

5.  Antibodies to the heparan sulfate proteoglycans synthesized by endothelial cell cultures.

Authors:  V Buonassisi; P Colburn
Journal:  Biochim Biophys Acta       Date:  1983-10-04

6.  Microvascular heparin-like species with anticoagulant activity.

Authors:  J A Marcum; L Fritze; S J Galli; G Karp; R D Rosenberg
Journal:  Am J Physiol       Date:  1983-11

7.  Anti-clotting activity of endothelial cell cultures and heparan sulfate proteoglycans.

Authors:  P Colburn; V Buonassisi
Journal:  Biochem Biophys Res Commun       Date:  1982-01-15       Impact factor: 3.575

8.  Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.

Authors:  E A Jaffe; R L Nachman; C G Becker; C R Minick
Journal:  J Clin Invest       Date:  1973-11       Impact factor: 14.808

9.  Changes in cell-surface glycosaminoglycans in human diploid fibroblasts during in vitro aging.

Authors:  K Matuoka; Y Mitsui
Journal:  Mech Ageing Dev       Date:  1981-02       Impact factor: 5.432

10.  The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.

Authors:  R Ross
Journal:  J Cell Biol       Date:  1971-07       Impact factor: 10.539

  10 in total

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