Literature DB >> 3996442

Ru-labeled ruthenocenoyl-glycine: comparison of clearance with hippuran.

M Wenzel, H Meinhold, G Schachschneider.   

Abstract

Ruthenocenoyl-glycine (ruppuran) is a metallocene analog of iodo-labeled hippuran. After injection of 103Ru-labeled ruppuran and ruthenocenoyl-1,1'-diglycine in rabbits, measurement with external detectors revealed a very rapid accumulation in the kidneys followed by rapid excretion of the 103Ru activity. By measurement of the radioactivity concentration in plasma and urine samples collected 1-60 min after IV injection, the plasma clearance was calculated and compared with the clearance of 125I-labeled hippuran injected simultaneously. The clearance of ruppuran and ruthenocenoyl-diglycine in rabbits was found to be somewhat higher than that of hippuran. Extrapolating to man (1.73 m3), plasma clearance with both ruthenocene derivatives was approximately 500-600 ml/min. Biochemical data as well as the nuclear properties of 97Ru indicate the usefulness of 97Ru-labeled ruthenocenoyl-glycine as a radiopharmaceutical for kidney function studies.

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Year:  1985        PMID： 3996442     DOI： 10.1007/bf00252722

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  14 in total

1.  Letter: The preparation of iodine-123 labelled sodium ortho-iodo hippurate and its clearance by the rat kidneys.

Authors:  M L Thakur; B M Chauser; R F Hudson
Journal:  Int J Appl Radiat Isot       Date:  1975-05

2.  [Affinity of adrenal glands for gamma emittor 103Ru as acetylruthenocen].

Authors:  M Wenzel; N Subramanian; E Nipper
Journal:  Naturwissenschaften       Date:  1976-07

3.  Iodohippurate sodium 131-I (OIH) clearance in mice bioassay of radiopharmaceuticals.

Authors:  T Konikowski; T P Hayhie; H J Glenn; L E Farr
Journal:  Proc Soc Exp Biol Med       Date:  1971-09

4.  Prediction of urinary excretion of 131I-orthoiodohippurate.

Authors:  W N Tauxe; E V Dubovsky; T Kidd; L R Smith; R Lewis; R Rivera
Journal:  Eur J Nucl Med       Date:  1982

5.  Dosimetry of renal radiopharmaceuticals: the importance of bladder radioactivity and a simple aid for its estimation.

Authors:  T Smith; N Veall; D G Altman
Journal:  Br J Radiol       Date:  1981-11       Impact factor: 3.039

6.  [Metabolism of 103 Ru-ruthenocene--in vitro experiments and a possible in vivo test for hydroxylases].

Authors:  M Wenzel; M Schneider; J Macha
Journal:  Int J Appl Radiat Isot       Date:  1981-11

7.  [Analog of hippuran: (103 Ru)ruthenocenoyl-glycine derivative. Synthesis, organ distribution and clearance].

Authors:  M Wenzel; G Schachschneider
Journal:  Z Naturforsch C Biosci       Date:  1983 Sep-Oct

8.  97Ru-DMSA for delayed renal imaging.

Authors:  Z H Oster; P Som; M C Gil; A G Goldman; R G Fairchild; G E Meinken; S C Srivastava; H L Atkins; P Richards; A B Brill
Journal:  Radiology       Date:  1981-10       Impact factor: 11.105

9.  Ruthenium-97 DTPA: a new radiopharmaceutical for cisternography.

Authors:  Z H Oster; P Som; M C Gil; R G Fairchild; A G Goldman; E R Schachner; D F Sacker; H L Atkins; G E Meinken; S C Srivastava; P Richards; A B Brill
Journal:  J Nucl Med       Date:  1981-03       Impact factor: 10.057

10.  Chemical and biological studies of Tc-99m N,N'-bis(mercaptoacetamido)-ethylenediamine: a potential replacement for I-131 iodohippurate.

Authors:  A R Fritzberg; W C Klingensmith; W P Whitney; C C Kuni
Journal:  J Nucl Med       Date:  1981-03       Impact factor: 10.057
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  1 in total

1.  Brain affinity of the ruthenocene analogue of N-isopropyl-amphetamine labeled with gamma-emitters.

Authors:  M Wenzel; D Preiss
Journal:  Naturwissenschaften       Date:  1986-08
  1 in total

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