| Literature DB >> 3995651 |
Abstract
Guanosine alkylated at the 7-position readily decomposed by imidazole ring opening and depurination. There is a direct correlation between the electron-withdrawing effects, expressed as the Taft substituent constant sigma*, of various alkylsubstituents in 7-position and the respective acid dissociation constants and chemical stabilities of 7-alkylated guanosines. The respective values for the slopes of the regression lines were rho* = +1.89 for imidazole ring opening and rho* = +0.175 for the depurination reaction. Unknown Taft constants can be determined from the sigma*/pKa regression line.Entities:
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Year: 1985 PMID： 3995651 DOI： 10.1016/s0009-2797(85)80094-6
Source DB: PubMed Journal: Chem Biol Interact ISSN： 0009-2797 Impact factor: 5.192