Melanoma among southwestern American Indians.

All forms of skin cancer are uncommon among southwestern American Indians. The estimated average annual incidence of melanoma is approximately 1 per hundred thousand population or less than one tenth of that currently reported for Anglos (non-Hispanic whites) residing in the same region. This study correlates the clinical and pathologic features of melanoma in 18 American Indian patients. A marked predilection for palms, soles, and subungual locations was displayed. Additionally, three patients presented with mucous membrane primaries and two with ocular melanomas. Advanced disease stage at diagnosis was common. The protective influence of natural pigmentation in skin cancer is discussed.