Literature DB >> 3995065

Formation of 15-HETE as a major hydroxyeicosatetraenoic acid in the atherosclerotic vessel wall.

P Henriksson, M Hamberg, U Diczfalusy.   

Abstract

Atherosclerosis was induced in New Zealand White rabbits through cholesterol feeding. Aortae were taken out from treated animals and incubated with arachidonic acid. Aortae from cholesterol-fed animals converted arachidonic acid into 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE). This conversion was not seen in aortae from control animals. The immediate precursor of 15-HETE, 15-HPETE, is an inhibitor of prostacyclin synthetase and might hamper prostacyclin production.

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Year:  1985        PMID： 3995065     DOI： 10.1016/0005-2760(85)90166-3

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  31 in total

1.  PPARs and lipid ligands in inflammation and metabolism.

Authors:  Gregory S Harmon; Michael T Lam; Christopher K Glass
Journal:  Chem Rev       Date:  2011-10-12       Impact factor: 60.622

2.  ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation.

Authors:  Sivareddy Kotla; Nikhlesh K Singh; James G Traylor; A Wayne Orr; Gadiparthi N Rao
Journal:  Free Radic Biol Med       Date:  2014-08-23       Impact factor: 7.376

3.  Oral 15-Hydroxyeicosatetraenoic Acid Induces Pulmonary Hypertension in Mice by Triggering T Cell-Dependent Endothelial Cell Apoptosis.

Authors:  Grégoire Ruffenach; Ellen O'Connor; Mylène Vaillancourt; Jason Hong; Nancy Cao; Shervin Sarji; Shayan Moazeni; Jeremy Papesh; Victor Grijalva; Christine M Cunningham; Le Shu; Arnab Chattopadhyay; Shuchita Tiwari; Olaf Mercier; Frédéric Perros; Soban Umar; Xia Yang; Aldrin V Gomes; Alan M Fogelman; Srinivasa T Reddy; Mansoureh Eghbali
Journal:  Hypertension       Date:  2020-07-27       Impact factor: 10.190

4.  Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis.

Authors:  Shunxing Rong; Qiang Cao; Mingxia Liu; Jeongmin Seo; Lin Jia; Elena Boudyguina; Abraham K Gebre; Perry L Colvin; Thomas L Smith; Robert C Murphy; Nilamadhab Mishra; John S Parks
Journal:  J Lipid Res       Date:  2012-01-25       Impact factor: 5.922

5.  Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

Authors:  S Ylä-Herttuala; M E Rosenfeld; S Parthasarathy; C K Glass; E Sigal; J L Witztum; D Steinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

6.  AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis.

Authors:  Nikhlesh K Singh; Dong Van Quyen; Venkatesh Kundumani-Sridharan; Peter C Brooks; Gadiparthi N Rao
Journal:  J Biol Chem       Date:  2010-03-29       Impact factor: 5.157

7.  Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C ε-mediated zona occludens-1 phosphorylation at threonine 770/772.

Authors:  Rima Chattopadhyay; Elena Dyukova; Nikhlesh K Singh; Motoi Ohba; James A Mobley; Gadiparthi N Rao
Journal:  J Biol Chem       Date:  2013-12-15       Impact factor: 5.157

8.  The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosis.

Authors:  Sivareddy Kotla; Nikhlesh K Singh; Mark R Heckle; Gabor J Tigyi; Gadiparthi N Rao
Journal:  Sci Signal       Date:  2013-09-17       Impact factor: 8.192

9.  12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction.

Authors:  Venkatesh Kundumani-Sridharan; Elena Dyukova; Dale E Hansen; Gadiparthi N Rao
Journal:  J Biol Chem       Date:  2013-04-15       Impact factor: 5.157

10.  15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression.

Authors:  Venkatesh Kundumani-Sridharan; Jixiao Niu; Dong Wang; Dong Van Quyen; Qiuhua Zhang; Nikhlesh K Singh; Jaganathan Subramani; Saradasri Karri; Gadiparthi N Rao
Journal:  Blood       Date:  2010-01-06       Impact factor: 22.113
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