Literature DB >> 3994710

Short-term stimulation of lipogenesis by triiodothyronine in maintenance cultures of rat hepatocytes.

G V Gnoni, M J Geelen, C Bijleveld, E Quagliariello, S G van den Bergh.   

Abstract

Within 4 h following the addition of 3,3',5 triiodo-L-thyronine to monolayer cultures of hepatocytes isolated from hypothyroid rats, a very distinct stimulation of fatty acid and cholesterol synthesis, measured as incorporation of either [1-14C]acetate or [3H]H2O into these lipid fractions, is observed. A smaller but significant increase in the rate of lipogenesis occurs in hepatocytes derived from euthyroid animals. These stimulatory effects of triiodothyronine are also observed in the presence of cycloheximide, indicating that the described early and direct stimulation of lipogenesis by the thyroid hormone is, at least in part, independent of protein synthesis.

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Year:  1985        PMID： 3994710     DOI： 10.1016/0006-291x(85)90078-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice.

Authors:  Fengxia Ge; Shengli Zhou; Chunguang Hu; Harrison Lobdell; Paul D Berk
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2010-07-01       Impact factor: 4.052

2.  Effect of L-triiodothyronine on delta 9 desaturase activity in liver microsomes of male rats.

Authors:  A Ves-Losada; R O Peluffo
Journal:  Lipids       Date:  1989-11       Impact factor: 1.880

3.  Rapid stimulation of hepatic oxygen consumption by 3,5-di-iodo-L-thyronine.

Authors:  C Horst; H Rokos; H J Seitz
Journal:  Biochem J       Date:  1989-08-01       Impact factor: 3.857

4.  MDA-9/syntenin is essential for factor VIIa-induced signaling, migration, and metastasis in melanoma cells.

Authors:  Hanaa Aissaoui; Célia Prévost; Ahmed Boucharaba; Kamel Sanhadji; Jean-Claude Bordet; Claude Négrier; Habib Boukerche
Journal:  J Biol Chem       Date:  2014-12-10       Impact factor: 5.157

5.  Triiodo-L-thyronine stimulates glycogen synthesis in rat hepatocyte cultures.

Authors:  S Betley; M Peak; L Agius
Journal:  Mol Cell Biochem       Date:  1993-03-24       Impact factor: 3.396

6.  Nuclear factor-kappaB is a critical mediator of Ste20-like proline-/alanine-rich kinase regulation in intestinal inflammation.

Authors:  Yutao Yan; Guillaume Dalmasso; Hang Thi Thu Nguyen; Tracy S Obertone; Laetitia Charrier-Hisamuddin; Shanthi V Sitaraman; Didier Merlin
Journal:  Am J Pathol       Date:  2008-09-11       Impact factor: 4.307

7.  Oleic Acid and Hydroxytyrosol Inhibit Cholesterol and Fatty Acid Synthesis in C6 Glioma Cells.

Authors:  Paola Priore; Antonio Gnoni; Francesco Natali; Mariangela Testini; Gabriele V Gnoni; Luisa Siculella; Fabrizio Damiano
Journal:  Oxid Med Cell Longev       Date:  2017-12-24       Impact factor: 6.543

Review 8.  Action of Thyroid Hormones, T3 and T2, on Hepatic Fatty Acids: Differences in Metabolic Effects and Molecular Mechanisms.

Authors:  Fabrizio Damiano; Alessio Rochira; Antonio Gnoni; Luisa Siculella
Journal:  Int J Mol Sci       Date:  2017-03-31       Impact factor: 5.923

9.  Ste20-related proline/alanine-rich kinase (SPAK) regulated transcriptionally by hyperosmolarity is involved in intestinal barrier function.

Authors:  Yutao Yan; Guillaume Dalmasso; Hang Thi Thu Nguyen; Tracy S Obertone; Shanthi V Sitaraman; Didier Merlin
Journal:  PLoS One       Date:  2009-04-03       Impact factor: 3.240
  9 in total

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