Literature DB >> 3993928

Use of digitonin fractionation to determine mitochondrial transmembrane ion distribution in cells during anoxia.

B S Andersson, D P Jones.   

Abstract

A method to determine intracellular distribution of ions and metabolites under conditions of low oxygen concentration was developed. The technique involves rapid digitonin fractionation and addition of cyanide to inhibit reoxygenation. Applicability of the procedure was examined by studying the distribution of the lipophilic ion triphenylmethylphosphonium, the weak acid 5,5-dimethyloxazolidine-2,4-dione, and adenine nucleotides.

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Year:  1985        PMID： 3993928     DOI： 10.1016/0003-2697(85)90411-7

Source DB:  PubMed          Journal:  Anal Biochem        ISSN： 0003-2697            Impact factor:   3.365


  13 in total

1.  Enterocyte viability and mitochondrial function after graded intestinal ischemia and reperfusion in rats.

Authors:  M Madesh; L Bhaskar; K A Balasubramanian
Journal:  Mol Cell Biochem       Date:  1997-02       Impact factor: 3.396

2.  Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice.

Authors:  Leonard W Velsor; Chirag Kariya; Remy Kachadourian; Brian J Day
Journal:  Am J Respir Cell Mol Biol       Date:  2006-06-08       Impact factor: 6.914

3.  Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death.

Authors:  G J Gores; A L Nieminen; B E Wray; B Herman; J J Lemasters
Journal:  J Clin Invest       Date:  1989-02       Impact factor: 14.808

4.  Disruption of pyridine nucleotide redox status during oxidative challenge at normal and low-glucose states: implications for cellular adenosine triphosphate, mitochondrial respiratory activity, and reducing capacity in colon epithelial cells.

Authors:  Magdalena L Circu; Ronald E Maloney; Tak Yee Aw
Journal:  Antioxid Redox Signal       Date:  2011-03-16       Impact factor: 8.401

5.  Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase.

Authors:  T M Hagen; D L Yowe; J C Bartholomew; C M Wehr; K L Do; J Y Park; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205

6.  Effect of chronic ethanol feeding on rat hepatocytic glutathione. Compartmentation, efflux, and response to incubation with ethanol.

Authors:  J C Fernandez-Checa; M Ookhtens; N Kaplowitz
Journal:  J Clin Invest       Date:  1987-07       Impact factor: 14.808

7.  Contribution of glutathione status to oxidant-induced mitochondrial DNA damage in colonic epithelial cells.

Authors:  Magdalena L Circu; Mary P Moyer; Lynn Harrison; Tak Yee Aw
Journal:  Free Radic Biol Med       Date:  2009-08-06       Impact factor: 7.376

8.  Comparison of the methods for determining cell-surface and intracellular receptors for epidermal growth factor in the rat liver.

Authors:  S Yanai; Y Sugiyama; T Iga; T Fuwa; M Hanano
Journal:  Pharm Res       Date:  1991-05       Impact factor: 4.200

9.  Glucose regulation of hydroperoxide metabolism in rat intestinal cells. Stimulation of reduced nicotinamide adenine dinucleotide phosphate supply.

Authors:  T Y Aw; C A Rhoads
Journal:  J Clin Invest       Date:  1994-12       Impact factor: 14.808

10.  Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis.

Authors:  Magdalena L Circu; Cynthia Rodriguez; Ronald Maloney; Mary Pat Moyer; Tak Yee Aw
Journal:  Free Radic Biol Med       Date:  2007-09-25       Impact factor: 7.376
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