| Literature DB >> 3992021 |
L J Smith, A M Sussman, M Serra, J J Buccafusco.
Abstract
Chronic administration of clonidine in the drinking water of spontaneously hypertensive (SH) rats from 11 through 17 weeks of age prevented the further development of hypertension in this model. A dosage adjustment (from about 0.1 to 0.5 mg/kg) was required to maintain a stable systolic pressure of about 200 mmHg. After six weeks of treatment clonidine was withheld for 48 hrs during which time blood pressure increased to a level similar to that of untreated controls.Entities:
Mesh：
Substances：
Year: 1985 PMID： 3992021
Source DB: PubMed Journal: Res Commun Chem Pathol Pharmacol ISSN： 0034-5164