Literature DB >> 3990894

Comparison of the binding of optically pure (-)- and (+)- [3H]nicotine to rat brain membranes.

L G Abood, S Grassi, H D Noggle.   

Abstract

A comparison of the binding of (-)- and (+)-[3H]nicotine to rat brain membranes revealed that only the (-)-enantiomer showed high affinity binding; while the (+)-enantiomer was at least 1/10 as effective as the (-)-enantiomer when in competition with (-)-[3H]nicotine as the ligand. Positive cooperativity, which is observed with (-)-[3H]nicotine in the presence of low concentrations of (+)-nicotine, may account for the seeming paradox.

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Year:  1985        PMID： 3990894     DOI： 10.1007/bf00964572

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  6 in total

1.  Separation of d-(+)-Nicotine from a Racemic Mixture by Stereospecific Degradation of the l-(-) Isomer with Pseudomonas putida.

Authors:  M C Detraglia; A M Tometsko
Journal:  Appl Environ Microbiol       Date:  1980-05       Impact factor: 4.792

2.  Stereospecific nicotine receptors on rat brain membranes.

Authors:  C Romano; A Goldstein
Journal:  Science       Date:  1980-11-07       Impact factor: 47.728

3.  Sites and mechanisms for nicotine's action in the brain.

Authors:  L G Abood; D T Reynolds; H Booth; J M Bidlack
Journal:  Neurosci Biobehav Rev       Date:  1981       Impact factor: 8.989

4.  Characterization of nicotine binding in mouse brain and comparison with the binding of alpha-bungarotoxin and quinuclidinyl benzilate.

Authors:  M J Marks; A C Collins
Journal:  Mol Pharmacol       Date:  1982-11       Impact factor: 4.436

5.  Noncholinergic, saturable binding of (+/-)-[3H]nicotine to mouse brain.

Authors:  H Sershen; M E Reith; A Lajtha; J Gennaro
Journal:  J Recept Res       Date:  1981

6.  Binding of optically pure (--)-[3H]nicotine to rat brain membranes.

Authors:  L G Abood; S Grassi; M Costanza
Journal:  FEBS Lett       Date:  1983-06-27       Impact factor: 4.124
  6 in total
  4 in total

1.  A comparison of the binding of nicotine and nornicotine stereoisomers to nicotinic binding sites in rat brain cortex.

Authors:  J R Copeland; A Adem; P Jacob; A Nordberg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-02       Impact factor: 3.000

2.  Evidence for an olfactory receptor which responds to nicotine--nicotine as an odorant.

Authors:  D A Edwards; R A Mather; S G Shirley; G H Dodd
Journal:  Experientia       Date:  1987-08-15

3.  The competition of (-)-[3H]nicotine binding by the enantiomers of nicotine, nornicotine and anatoxin-a in membranes and solubilized preparations of different brain regions of rat.

Authors:  X Zhang; A Nordberg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-07       Impact factor: 3.000

4.  Application of carbon-11 labelled nicotine in the measurement of human cerebral blood flow and other physiological parameters.

Authors:  F Yokoi; T Komiyama; T Ito; T Hayashi; M Lio; T Hara
Journal:  Eur J Nucl Med       Date:  1993-01
  4 in total

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