Literature DB >> 3990293

A new defect in the peripheral conversion of cortisone to cortisol.

G Phillipou, B A Higgins.   

Abstract

A steroid disorder is described in two sisters, aged 13 and 17 years, in which the metabolism of cortisol results almost exclusively in urinary excretion of tetrahydro-cortisone (11-keto) derivatives. The evidence implies the existence of a deficiency in the peripheral enzymatic conversion of cortisone to cortisol.

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Year:  1985        PMID： 3990293     DOI： 10.1016/0022-4731(85)90451-0

Source DB:  PubMed          Journal:  J Steroid Biochem        ISSN： 0022-4731            Impact factor:   4.292


  7 in total

Review 1.  Apparent mineralocorticoid excess syndromes.

Authors:  M Shimojo; P M Stewart
Journal:  J Endocrinol Invest       Date:  1995 Jul-Aug       Impact factor: 4.256

2.  Mutations of the hexose-6-phosphate dehydrogenase gene rarely cause hyperandrogenemic polycystic ovary syndrome.

Authors:  Kenan Qin; Robert L Rosenfield
Journal:  Steroids       Date:  2010-11-02       Impact factor: 2.668

3.  11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress.

Authors:  Y Kotelevtsev; M C Holmes; A Burchell; P M Houston; D Schmoll; P Jamieson; R Best; R Brown; C R Edwards; J R Seckl; J J Mullins
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-23       Impact factor: 11.205

4.  Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle.

Authors:  P M Stewart; J E Corrie; C H Shackleton; C R Edwards
Journal:  J Clin Invest       Date:  1988-07       Impact factor: 14.808

5.  The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome.

Authors:  Minghan Wang
Journal:  Nutr Metab (Lond)       Date:  2005-02-02       Impact factor: 4.169

Review 6.  Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS).

Authors:  Nils Krone; Beverly A Hughes; Gareth G Lavery; Paul M Stewart; Wiebke Arlt; Cedric H L Shackleton
Journal:  J Steroid Biochem Mol Biol       Date:  2010-04-22       Impact factor: 4.292

7.  Novel H6PDH mutations in two girls with premature adrenarche: 'apparent' and 'true' CRD can be differentiated by urinary steroid profiling.

Authors:  G G Lavery; J Idkowiak; M Sherlock; I Bujalska; J P Ride; K Saqib; M F Hartmann; B Hughes; S A Wudy; J De Schepper; W Arlt; N Krone; C H Shackleton; E A Walker; P M Stewart
Journal:  Eur J Endocrinol       Date:  2013-02-01       Impact factor: 6.664
  7 in total

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