Literature DB >> 3988741

Trypanosoma brucei variant surface glycoprotein has a sn-1,2-dimyristyl glycerol membrane anchor at its COOH terminus.

M A Ferguson, K Haldar, G A Cross.   

Abstract

The membrane form of Trypanosoma brucei variant surface glycoprotein (mfVSG) is acylated with ester-linked tetradecanoic (myristic) acid (Ferguson, M. A. J., and Cross, G. A. M. (1984) J. Biol. Chem. 259, 3011-3015). Comparative analysis of Pronase peptides from mfVSG and soluble VSG localizes the site of mfVSG acylation to a COOH-terminal oligosaccharide structure. Chemical and enzymatic treatment of the acylated Pronase mfVSG fragment revealed that the myristic acid is present as a diglyceride (sn-1,2-dimyristin) that is probably linked to the COOH-terminal oligosaccharide via a phosphodiester bond between the sn-3-glycerol hydroxyl and a sugar hydroxyl group. The endogenous membrane-associated enzyme, which quantitatively cleaves myristic acid from mfVSG to produce soluble VSG, releases diglyceride, as would be expected of a phospholipase C.

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Year:  1985        PMID： 3988741

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  59 in total

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Review 5.  Modification of proteins with covalent lipids.

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7.  Identification of the parasite transferrin receptor of Plasmodium falciparum-infected erythrocytes and its acylation via 1,2-diacyl-sn-glycerol.

Authors:  K Haldar; C L Henderson; G A Cross
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

8.  Glycotyping of Trypanosoma brucei variant surface glycoprotein MITat1.8.

Authors:  Angela Mehlert; Lauren Sullivan; Michael A J Ferguson
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9.  The glycosylphosphatidylinositol-PLC in Trypanosoma brucei forms a linear array on the exterior of the flagellar membrane before and after activation.

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10.  Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases.

Authors:  Luis Izquierdo; Benjamin L Schulz; João A Rodrigues; Maria Lucia S Güther; James B Procter; Geoffrey J Barton; Markus Aebi; Michael A J Ferguson
Journal:  EMBO J       Date:  2009-07-23       Impact factor: 11.598
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