Literature DB >> 3988730

Biosynthesis of the beta-lactam antibiotic, thienamycin, by Streptomyces cattleya.

J M Williamson, E Inamine, K E Wilson, A W Douglas, J M Liesch, G Albers-Schönberg.   

Abstract

Radioactive- and stable isotope-containing substrates were used to identify the biosynthetic precursors of the beta-lactam antibiotic, thienamycin, in Streptomyces cattleya. Acetate is utilized by the organism to form C(6) and C(7) of the beta-lactam ring. The two carbons of the hydroxyethyl group attached to C(6) are both derived from the methyl of methionine. The cysteaminyl side chain attached to C(2) is derived from cysteine. Selective inhibition of thienamycin and cephamycin C biosynthesis has been achieved either through the addition of metabolic inhibitors or through manipulation of the growth medium. These results suggest that the two beta-lactam antibiotics, thienamycin and cephamycin C, are formed by different biosynthetic pathways.

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Year:  1985        PMID： 3988730

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  22 in total

1.  Methionine interference in rapamycin production involves repression of demethylrapamycin methyltransferase and S-adenosylmethionine synthetase.

Authors:  W S Kim; Y Wang; A Fang; A L Demain
Journal:  Antimicrob Agents Chemother       Date:  2000-10       Impact factor: 5.191

2.  Methylations in complex carbapenem biosynthesis are catalyzed by a single cobalamin-dependent radical S-adenosylmethionine enzyme.

Authors:  Erica K Sinner; Michael S Lichstrahl; Rongfeng Li; Daniel R Marous; Craig A Townsend
Journal:  Chem Commun (Camb)       Date:  2019-12-10       Impact factor: 6.222

Review 3.  Targeting the Achilles' Heel of Bacteria: Different Mechanisms To Break Down the Peptidoglycan Cell Wall during Bacterial Warfare.

Authors:  Stephanie Sibinelli-Sousa; Julia Takuno Hespanhol; Ethel Bayer-Santos
Journal:  J Bacteriol       Date:  2021-03-08       Impact factor: 3.490

4.  A cofactor for thienamycin biosynthesis produced by a blocked mutant of Streptomyces cattleya.

Authors:  T S Chen; B H Arison; C L Ruby; A W Dombrowski; E S Inamine
Journal:  J Ind Microbiol       Date:  1993-01

5.  Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis.

Authors:  Micah J Bodner; Rongfeng Li; Ryan M Phelan; Michael F Freeman; Kristos A Moshos; Evan P Lloyd; Craig A Townsend
Journal:  Chembiochem       Date:  2011-08-24       Impact factor: 3.164

6.  Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics.

Authors:  Micah J Bodner; Ryan M Phelan; Michael F Freeman; Rongfeng Li; Craig A Townsend
Journal:  J Am Chem Soc       Date:  2010-01-13       Impact factor: 15.419

7.  Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis.

Authors:  Michael F Freeman; Kristos A Moshos; Micah J Bodner; Rongfeng Li; Craig A Townsend
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-04       Impact factor: 11.205

8.  Identification, characterization, and regulation of a cluster of genes involved in carbapenem biosynthesis in Photorhabdus luminescens.

Authors:  Sylviane Derzelle; Eric Duchaud; Frank Kunst; Antoine Danchin; Philippe Bertin
Journal:  Appl Environ Microbiol       Date:  2002-08       Impact factor: 4.792

9.  N-(3-oxohexanoyl)-L-homoserine lactone regulates carbapenem antibiotic production in Erwinia carotovora.

Authors:  N J Bainton; P Stead; S R Chhabra; B W Bycroft; G P Salmond; G S Stewart; P Williams
Journal:  Biochem J       Date:  1992-12-15       Impact factor: 3.857

Review 10.  Directed evolution and rational approaches to improving Streptomyces clavuligerus deacetoxycephalosporin C synthase for cephalosporin production.

Authors:  Kian-Sim Goo; Chun-Song Chua; Tiow-Suan Sim
Journal:  J Ind Microbiol Biotechnol       Date:  2009-03-07       Impact factor: 3.346
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