Literature DB >> 3987891

Tissue-specific modulation of the mitochondrial calcium uniporter by magnesium ions.

M Favaron, P Bernardi.   

Abstract

This paper analyzes the kinetics of the Ca2+ uniporter of mitochondria from rat heart, kidney and liver operating in a range of Ca2+ concentrations near the steady-state value (1-4 microM). Heart mitochondria exhibit the lowest activity, and physiological Mg2+ concentrations inhibit the mitochondrial Ca2+ uniporter by approx. 50% in heart and kidney, and by 20% in liver. At physiological Ca2+ and Mg2+ concentrations the external free Ca2+ maintained by respiring mitochondria in vitro is higher in heart and kidney with respect to liver mitochondria. This behaviour could represent an adaptation of different mitochondria to their specific intracellular environment.

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Year:  1985        PMID： 3987891     DOI： 10.1016/0014-5793(85)80789-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  22 in total

Review 1.  Possible pharmacological actions of magnesium in acute myocardial infarction.

Authors:  K L Woods
Journal:  Br J Clin Pharmacol       Date:  1991-07       Impact factor: 4.335

2.  Mitochondrial Ca2+ influx and efflux rates in guinea pig cardiac mitochondria: low and high affinity effects of cyclosporine A.

Authors:  An-Chi Wei; Ting Liu; Sonia Cortassa; Raimond L Winslow; Brian O'Rourke
Journal:  Biochim Biophys Acta       Date:  2011-02-26

3.  Pathways for Ca2+ efflux in heart and liver mitochondria.

Authors:  R Rizzuto; P Bernardi; M Favaron; G F Azzone
Journal:  Biochem J       Date:  1987-09-01       Impact factor: 3.857

Review 4.  Investigational therapies for ischemic stroke: neuroprotection and neurorecovery.

Authors:  Preeti Sahota; Sean I Savitz
Journal:  Neurotherapeutics       Date:  2011-07       Impact factor: 7.620

5.  Serum magnesium but not calcium was associated with hemorrhagic transformation in stroke overall and stroke subtypes: a case-control study in China.

Authors:  Ge Tan; Ruozhen Yuan; ChenChen Wei; Mangmang Xu; Ming Liu
Journal:  Neurol Sci       Date:  2018-05-26       Impact factor: 3.307

6.  Magnesium sulphate only slightly reduces the shivering threshold in humans.

Authors:  A Wadhwa; P Sengupta; J Durrani; O Akça; R Lenhardt; D I Sessler; A G Doufas
Journal:  Br J Anaesth       Date:  2005-03-04       Impact factor: 9.166

7.  Extra-matrix Mg2+ limits Ca2+ uptake and modulates Ca2+ uptake-independent respiration and redox state in cardiac isolated mitochondria.

Authors:  Age D Boelens; Ranjan K Pradhan; Christoph A Blomeyer; Amadou K S Camara; Ranjan K Dash; David F Stowe
Journal:  J Bioenerg Biomembr       Date:  2013-03-03       Impact factor: 2.945

8.  Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations.

Authors:  Samuel K Lee; Santhanam Shanmughapriya; Mac C Y Mok; Zhiwei Dong; Dhanendra Tomar; Edmund Carvalho; Sudarsan Rajan; Murray S Junop; Muniswamy Madesh; Peter B Stathopulos
Journal:  Cell Chem Biol       Date:  2016-08-25       Impact factor: 8.116

Review 9.  Role of magnesium in reducing mortality in acute myocardial infarction. A review of the evidence.

Authors:  Koon K Teo; Salim Yusuf
Journal:  Drugs       Date:  1993-09       Impact factor: 9.546

Review 10.  Magnesium in stroke treatment.

Authors:  K W Muir
Journal:  Postgrad Med J       Date:  2002-11       Impact factor: 2.401
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