| Literature DB >> 3987817 |
Abstract
Supersensitivity to apomorphine's inhibitory effect on dopamine neurons was induced in Sprague-Dawley rats by chronically administering haloperidol. It is concluded that the increased sensitivity of dopamine neurons to apomorphine may be linked to its influence on autoreceptors. The possibility that autoreceptor supersensitivity could contribute to enhancement of antipsychotic therapy is discussed.Entities:
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Year: 1985 PMID： 3987817 DOI： 10.1016/0014-2999(85)90222-5
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432