Literature DB >> 3987802

Effect of calcium entry blockade on ethanol-induced changes in bronchomotor tone.

C Lombardi, C Spedini, S Govoni.   

Abstract

The effect of various Calcium Entry Blockers (CEBs; nifedipine, flunarizine, diltiazem, verapamil) on ethanol-induced bronchoconstriction was studied in normal healthy volunteers. Nifedipine and diltiazem inhibited the bronchoconstriction and verapamil and flunarizine had no effect. The data favour the general hypothesis of differential tissue sensitivity to the various CEBs. The activity of CEBs on bronchomotor tone may be of therapeutic value in patients in whom bronchodilator activity is recommended in addition to the cardiovascular action.

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Year:  1985        PMID： 3987802     DOI： 10.1007/bf00609695

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  8 in total

Review 1.  Calcium antagonists: a new class of drugs.

Authors:  W G Nayler; J D Horowitz
Journal:  Pharmacol Ther       Date:  1983       Impact factor: 12.310

2.  Effects of nifedipine on antigen-induced bronchoconstriction.

Authors:  A F Henderson; R W Heaton; L S Dunlop; J F Costello
Journal:  Am Rev Respir Dis       Date:  1983-05

3.  Effect of nifedipine on bronchomotor tone and histamine reactivity in asthma.

Authors:  D O Williams; P J Barnes; H P Vickers; M Rudolf
Journal:  Br Med J (Clin Res Ed)       Date:  1981-08-01

4.  Maximal mid-expiratory flow (FEF25-75%): normal limits and assessment of sensitivity.

Authors:  R J Knudson; M D Lebowitz
Journal:  Am Rev Respir Dis       Date:  1978-03

5.  Changes in measured spirometric indices. What is significant?

Authors:  B E Pennock; R M Rogers; D R McCaffree
Journal:  Chest       Date:  1981-07       Impact factor: 9.410

6.  An investigation of the mechanism of ethanol-induced bronchoconstriction.

Authors:  E F Geppert; H A Boushey
Journal:  Am Rev Respir Dis       Date:  1978-07

7.  Alcohol-induced bronchospasm in an asthmatic patient: pharmacologic evaluation of the mechanism.

Authors:  H Gong; D P Tashkin; B M Calvarese
Journal:  Chest       Date:  1981-08       Impact factor: 9.410

8.  Lung function changes by ethanol inhalation.

Authors:  E Zuskin; A Bouhuys; M Sarić
Journal:  Clin Allergy       Date:  1981-05
  8 in total
  3 in total

Review 1.  Nifedipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in ischaemic heart disease, hypertension and related cardiovascular disorders.

Authors:  E M Sorkin; S P Clissold; R N Brogden
Journal:  Drugs       Date:  1985-09       Impact factor: 9.546

2.  Long-term treatment with oral nifedipine plus theophylline in the management of chronic bronchial asthma.

Authors:  C Spedini; C Lombardi
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

3.  The impact of extracellular and intracellular Ca2+ on ethanol-induced smooth muscle contraction.

Authors:  Naciye Yaktubay Döndaş; Mahir Kaplan; Derya Kaya; Ergin Singirik
Journal:  Acta Pharmacol Sin       Date:  2009-09-14       Impact factor: 6.150
  3 in total

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